Characterization and dietary regulation of glutamate dehydrogenase in different ploidy fishes

Amino Acids
Zhen LiuYun Liu

Abstract

Glutamate dehydrogenase (GDH) plays a crucial role in amino acid deamination and has been used as an inductor of nutrients metabolism. In this study, we cloned and analyzed the GDH cDNAs in diploids (red crucian carp), triploids and tetraploids and characterized their expression profiles upon dietary treatments. Results showed a high sequence similarity of GDH among the three kinds of ploidy fishes and other vertebrates. Expression analysis revealed that GDH exhibited a distinct spatial pattern of expression in different types of fishes. The triploids and tetraploids had higher levels of expression than diploids in heart, liver, gill, muscle, fore-gut and mid-gut. The GDH expression was also developmentally regulated with a stronger expression around blastula stage. The maternal GDH transcripts were first detected from eggs and their expression dropped down from the gastrula stage to heart beat stage. Adult triploids showed the highest levels of GDH expression in liver during breeding season which may contribute to the good appetite and fast growth. In addition, triploids exhibited high growth rates and excess GDH expression compared with other two types of fishes. The liver GDH enzyme activities were also higher in triploids t...Continue Reading

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Citations

Jan 24, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Louis DiVincentiDawn Dittman
Apr 26, 2017·Experimental Biology and Medicine·Olivia Vázquez-MartínezMauricio Díaz-Muñoz
Feb 14, 2018·Journal of Molecular Endocrinology·Carlos GasparIsidoro Metón
Jan 17, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ania RashidpourIsidoro Metón
Dec 5, 2019·International Journal of Molecular Sciences·Muhammad Shoaib AlamFarman Ullah Dawar
May 15, 2020·Amino Acids·Xinyu LiGuoyao Wu

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