Characterization and functional analyses of novel chicken leukocyte immunoglobulin-like receptor subfamily B members 4 and 5

Poultry Science
Anh Duc TruongYeong Ho Hong

Abstract

The inhibitory leukocyte immuno-globulin-like receptors (LILRBs) play an important role in innate immunity. Currently, no data exist regarding the role of LILRB4 and LILRB5 in the activation of immune signaling pathways in mammalian and avian species. Here, we report for the first time, the cloning and structural and functional analyses of chicken LILRB4-5 genes identified from 2 genetically disparate chicken lines. Comparison of LILRB4-5 amino acid sequences from lines 6.3 and 7.2 with those of mammalian proteins revealed 17 to 62% and 19 to 29% similarity, respectively. Phylogenetic analysis indicated that the chicken LILRB4-5 genes were closely associated with those of other species. LILRB4-5 could be subdivided into 2 groups having distinct immunoreceptor tyrosine-based inhibitory motifs, which bind to Src homology 2-containing tyrosine phosphatase 2 (SHP-2). Importantly, LILRB4-5 also upregulated the major histocompatibility complex (MHC) class I and β2-microglobulin gene expression as well as the expression of transporter associated with antigen processing 1-2, which play an important role in MHC class I activation. Our results indicate that LILRB4-5 are transcriptional regulators of the MHC class I pathway components and...Continue Reading

References

Nov 1, 1995·Cellular Signalling·D S Finbloom, A C Larner
Jun 1, 1997·Immunology Today·E Vivier, M Daëron
Oct 5, 2001·Clinical Microbiology Reviews·S W Chensue
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margaret A HolmesRoland K Strong
Jan 22, 2004·The Journal of Experimental Medicine·Martin HülsmeyerBarbara Uchanska-Ziegler
Apr 6, 2004·Trends in Pharmacological Sciences·Jan Vilcek, Marc Feldmann
Sep 8, 2009·Journal of Molecular Biology·André SchiefnerIan A Wilson
Jan 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Des C JonesRachel L Allen
Mar 8, 2014·PLoS Genetics·Arman A BashirovaXu G Yu
Sep 2, 2015·Asian-Australasian Journal of Animal Sciences·Anh Duc TruongHyun S Lillehoj
Nov 15, 2015·Science China. Life Sciences·FeiFei ZhangChengCheng Zhang
Aug 3, 2016·Journal of Animal Science·A D TruongH S Lillehoj
Mar 6, 2017·Developmental and Comparative Immunology·Anh Duc TruongYeong Ho Hong

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Citations

May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang

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