Characterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll of Undaria pinnatifida in Cyclophosphamide-Induced Immunosuppressed Mice

Marine Drugs
Hee Joon YooKwang-Won Lee

Abstract

Immunomodulation involves two mechanisms, immunostimulation and immunosuppression. It is a complex mechanism that regulates the pathophysiology and pathogenesis of various diseases affecting the immune system. Immunomodulators can be used as immunostimulators to reduce the side effects of drugs that induce immunosuppression. In this study, we characterized the chemical composition of high molecular weight fucoidan (HMWF) and low molecular weight fucoidan and compared their functions as natural killer (NK) cell-derived immunostimulators in vitro. We also tested the effectiveness of HMWF, which has a relatively high function in vitro, as an immunostimulator in immunosuppressed animal models. In these models, HWMF significantly restored NK cell cytotoxicity and granzyme B release to the control group level. In addition, the expression of interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-12, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α also increased in the spleen. This study suggests that HMWF acts as an effective immunostimulant under immunosuppressive conditions.

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Citations

Aug 24, 2019·Marine Drugs·Sibusiso LuthuliHaibin Tong
Mar 22, 2020·Marine Drugs·Ahmed Zayed, Roland Ulber
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shalini Sundramurthi ChelliahIshwar Parhar
Mar 9, 2021·Journal of the Science of Food and Agriculture·Ting SunHui Liang
Sep 2, 2021·Journal of Food Biochemistry·Somnath Basak, Jyoti Gokhale

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Assay
ELISA
reverse
PCR

Software Mentioned

SAS

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