Characterization and localization of the rat, mouse and human testicular phosphatidylethanolamine binding protein

Experientia
N SeddiqiF Schoentgen

Abstract

A cytosolic 23kDa protein was initially purified from bovine brain and shown to bind phosphatidylethanolamine. Later, it was also characterized in rat and human brain, and it is now known to be widespread, having been found in numerous tissues in several species. Here, we report the high level of mRNA and phosphatidyl ethanolamine binding protein expression in rat testis and to a lesser extent in mouse testis. In human testis, although it was not detectable by Northern blot analysis, the mRNA was shown to be present when PCR amplification was performed. Immunohistochemical experiments revealed that the testicular phosphatidylethanolamine binding protein (tPBP) is principally expressed in the elongated spermatids of both rat and mouse testis. This finding, and the association of tPBP with cellular membranes, suggest its possible implication in membrane remodelling during spermatid maturation.

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Citations

Oct 29, 1999·European Journal of Biochemistry·B ValléeF Schoentgen
Dec 20, 2002·DNA and Cell Biology·Cécilia MaubaretChristian P Hamel
Mar 25, 2009·Archives of Insect Biochemistry and Physiology·Gilles RautureauMartine Decoville
Jan 30, 2013·Journal of Cellular Physiology·Fahd Al-MullaKam C Yeung
Jun 2, 2005·The Journal of Toxicological Sciences·Toshinori YamamotoIkuo Horii
Jun 10, 2020·Reproduction in Domestic Animals = Zuchthygiene·Sunil Kumar PatilJanivara Parameshwaraiah Ravindra
Feb 3, 2007·Journal of Proteome Research·Antoine D RollandCharles Pineau

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