Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain

Journal of Neuroscience Research
Miriam KolkoNicolas G Bazan

Abstract

Secretory phospholipases A(2) (sPLA(2)) form a diverse family of enzymes involved in a variety of physiologic and pathologic processes. Common among all sPLA(2) is the ability to cleave the second position of phospholipids, thereby releasing fatty acid and a lysophospholipid. Several sPLA(2) have been cloned and characterized in various tissues and receptors have been identified. In the nervous system, sPLA(2) groups IB, IIA, IIE, IIF, V, and XII have been identified, and binding sites for sPLA(2) have been found. Here, we report sPLA(2)-IIE and sPLA(2)-X in rat brain as well as in neurons in primary culture. We furthermore confirm the presence of sPLA(2)-V in rat brain and demonstrate the presence of sPLA(2)-V in primary neuronal cultures. The distribution of sPLA(2)-IIE, V, and -X seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. We also find that sPLA(2)-IIE, -V, and -X are differentially induced by kainic acid. This study supports the concept that sPLA(2) heterogeneity in brain is functionally relevant and responsive to seizures.

References

Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M A DeCoster, D L Yourick
Jun 20, 1997·The Journal of Biological Chemistry·L CupillardG Lambeau
Sep 1, 1997·Journal of Neurochemistry·A A FarooquiL A Horrocks
Jan 14, 1999·Neuroscience Letters·G Y MolloyR J Williams
Feb 22, 2000·The Journal of Biological Chemistry·N SuzukiK Hanasaki
Jul 25, 2000·Neurochemical Research·A Sapirstein, J V Bonventre
Oct 14, 2000·The Journal of Biological Chemistry·M H GelbG Lambeau
Nov 18, 2000·Biochimica Et Biophysica Acta·D A Six, E A Dennis
Dec 9, 2000·Biochemical and Biophysical Research Communications·E ValentinG Lambeau
Oct 29, 2002·FEBS Letters·María A BalboaEdward A Dennis
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Ichiro Kudo, Makoto Murakami
Dec 4, 2003·Biochimica Et Biophysica Acta·Katsuhiko HamaguchiIchiro Kudo
Dec 6, 2003·Journal of Lipid Research·Grace Y SunAgnes Simonyi
Jul 21, 2004·Journal of Neuroscience Research·Miriam KolkoNicolas G Bazan
Jan 5, 2006·Cellular and Molecular Neurobiology·Miriam KolkoNicolas G Bazan

❮ Previous
Next ❯

Citations

Oct 27, 2009·Neuromolecular Medicine·Grace Y SunAgnes Simonyi
Mar 20, 2010·Molecular Neurobiology·Gianfrancesco GoracciVincenza Nardicchi
Oct 10, 2006·Journal of Neuroinflammation·Guna S D MosesGrace Y Sun
Oct 12, 2013·Molecular Neurobiology·Tatsurou YagamiHiromi Koma
Nov 29, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ho-Joo LeeRichard P Bazinet
Oct 24, 2007·Biochimica Et Biophysica Acta·Vincenza NardicchiGianfrancesco Goracci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.