Characterization and Neuroprotection Potential of Seleno-Polymannuronate

Frontiers in Pharmacology
Decheng BiXu Xu

Abstract

Seleno-polymannuronate (Se-PM) was prepared from alginate-derived polymannuronate (PM) through a sulfation followed by a selenylation replacement reaction. The organic selenium content of Se-PM was 437.25 μg/g and its average molecular weight was 2.36 kDa. The neuroprotection effect of Se-PM and corresponding molecular mechanisms were investigated. Our results showed that, comparing to both sulfated PM (S-PM) and PM, Se-PM remarkably inhibited the aggregation of Aβ1-42 oligomer in vitro and significantly reduced the APP and BACE1 protein expression in N2a-sw cells, highlighting the critical function of the selenium presented in Se-PM. Moreover, Se-PM decreased the expression of cytochrome c and the ratio of Bax to Bcl-2, and enhanced the mitochondrial membrane potential in N2a-sw cells. These results suggested that Se-PM treatment can markedly inhibit N2a-sw cell apoptosis and promote N2a-sw cell survival and that Se-PM might be a potential therapeutic agent for the prevention of neurodegeneration owing to its remarkable neuroprotection effect.

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Citations

Jun 4, 2020·Marine Drugs·Adrian Florian BălașaAlexandru Mihai Grumezescu
Feb 3, 2021·International Journal of Molecular Sciences·Shuangxue HanQingguo Xie
Apr 9, 2021·Journal of Agricultural and Food Chemistry·Decheng BiXu Xu
Jul 14, 2021·Critical Reviews in Food Science and Nutrition·Chunhua ZhangChunpeng Wan
Aug 9, 2021·Carbohydrate Polymers·Mingpeng WangZhaojie Zhang

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Methods Mentioned

BETA
circular dichroism
Fluorescence
confocal microscopy
nuclear

Software Mentioned

GraphPad
Quantity One
ImageJ
GraphPad prism

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