Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

Pharmaceutical Development and Technology
Pia ThyboAnette Mullertz

Abstract

The main purpose of this study was to obtain stable, well-characterized solid dispersions (SDs) of amorphous probucol and polyvinylpyrrolidone K-30 (PVP-K30) with improved dissolution rates. A secondary aim was to investigate the flow-through dissolution method for in-vitro dissolution measurements of small-sized amorphous powders dispersed in a hydrophilic polymer. SDs were prepared by spray drying solutions of probucol and different amounts of PVP-K30. The obtained SDs were characterized by dissolution rate measurements in a flow-through apparatus, X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), particle sizing (laser diffraction) and Brunauer-Emmett-Teller Method (BET) and results were compared with starting material and a physical mixture. The physical stability was monitored after storage at 25 degrees C and 60% RH for up to 12 weeks. The flow-through method was found suitable as dissolution method. All SDs showed improved in-vitro dissolution rates when compared to starting material and physical mixtures. The greatest improvement in the in-vitro dissolution rate was observed for the highest polymer to drug ratio. By means of the results from XRPD and DSC, it wa...Continue Reading

References

Aug 1, 1995·Journal of Pharmaceutical Sciences·M YoshiokaG Zografi
Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Mar 4, 1999·International Journal of Pharmaceutics·D Q CraigM L Hopton
Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P GiunchediM F Saettone
Sep 30, 1999·International Journal of Pharmaceutics·J Y JungK H Lee
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Leuner, J Dressman
Jan 5, 2002·International Journal of Pharmaceutics·Duncan Q M Craig
Mar 14, 2002·International Journal of Pharmaceutics·Shobha N BhattacharSuresh R Babu
Sep 19, 2002·Drug Development and Industrial Pharmacy·L H EmaraA Abd Elbary
Sep 1, 2004·International Journal of Pharmaceutics·Anshuman A AmbikeAnant Paradkar
Mar 1, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Vibeke Hougaard SunesenAnette Müllertz
Aug 20, 2005·Drug Development and Industrial Pharmacy·Evangelos KaravasEmmanouel Georgarakis
Sep 14, 2006·Pharmaceutical Research·Adchara PongpeerapatKeiji Yamamoto
Feb 3, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Evangelos KaravasDimitrios Bikiaris
May 9, 2007·Pharmaceutical Development and Technology·Pia ThyboLars Hovgaard

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Citations

Mar 1, 2012·The Journal of Chemical Physics·Daniel M LienhardThomas Peter
Jun 10, 2011·Journal of Pharmaceutical Sciences·David PahovnikEma Zagar
Jul 24, 2012·International Journal of Pharmaceutics·Amrit PaudelGuy Van den Mooter
Nov 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jin LiYong-Qing Fan
Aug 17, 2011·Advanced Drug Delivery Reviews·Jared A Baird, Lynne S Taylor
Dec 27, 2015·Advanced Drug Delivery Reviews·Abhishek Singh, Guy Van den Mooter
Jan 25, 2012·Pharmaceutical Development and Technology·Michael M LeaneAndrew B Dennis
Aug 31, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Edmund S KostewiczPatrick Augustijns
May 18, 2020·Polymers·Paola Franco, Iolanda De Marco
Aug 10, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Michael LauAlfonso E Garcia-Bennett
May 28, 2021·Molecular Pharmaceutics·Samarth D ThakoreArvind K Bansal
Aug 14, 2013·Molecular Pharmaceutics·Mamta Kapoor, Ronald A Siegel
Aug 10, 2021·ACS Applied Polymer Materials·Rahul UpadhyaAdam J Gormley
Oct 12, 2015·ACS Biomaterials Science & Engineering·Jeffrey M TingTheresa M Reineke

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