Characterization and prebiotic activity in vitro of inulin-type fructan from Codonopsis pilosula roots

Carbohydrate Polymers
Yu-Ping FuYuan-Feng Zou

Abstract

The inulin-type fructan was obtained by DEAE anion exchange chromatography from C. pilosula Nannf. var. modesta (Nannf.) L. T. Shen, after optimized extract condition, which was established by response surface methodology, designed using Box-Behnken factorial design and the optimum condition were: extracting 2.5 h with ratio of solvent to material 40 mL/g at 100 °C, twice. The maximum extraction yield was 20.6 ± 0.2%. It was confirmed as β-(2-1) linkage fructan, with terminal glucose, and with a degree of polymerization of 2-17 (DPav = 6), shown by the results of methanolysis, methylation, nuclear magnetic resonance and molecular weight determination. The prebiotic activity was proven on account of stimulation effect on Lactobacillus and pH reduction of medium in vitro. The results indicated that the inulin from C. pilosula could be used as a potential natural source of prebiotics.

Citations

Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Feng ZouZhong-Qiong Yin
Apr 23, 2020·Food & Function·Paweł GlibowskiAleksandra Kowalska
Jul 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu-Ping FuYuan-Feng Zou
Dec 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jiankuan LiJianping Gao
Apr 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·De-Jiang PangYuan-Feng Zou
Apr 17, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jiankuan LiJianping Gao
Jul 2, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Bao GongJian-Guo Liu

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