Characterization and significance of localized sources identified by a novel automated algorithm during mapping of human persistent atrial fibrillation

Journal of Cardiovascular Electrophysiology
Atul VermaTom de Potter

Abstract

Automated algorithms may identify focal (FA) and rotational (RoA) activations during persistent atrial fibrillation (PeAF). To evaluate an automated algorithm for characterizing and assessing significance of FA/RoA. Eighty-six PeAF ablation patients (1411 maps) were analyzed. Maps were obtained with a 64-electrode basket using CARTOFINDER, which filters/annotates atrial unipolar electrograms over 30 seconds. Operators ablated FA/RoA followed by pulmonary vein isolation (PVI). The automated algorithm was retrospectively applied using QS patterns to identify FA and sequential activation gradients for RoA without phase mapping. Algorithm-identified FA and RoA were validated against blinded adjudicators. Ablation of algorithm-identified FA/RoA was related to procedural AF termination. 73% ± 18% of electrodes (65% ± 11% atrial surface area) were adequate for analysis. Compared with adjudicators, the algorithm had a sensitivity of 84% for FA and 86% for RoA. There were 4 ± 2 FA and 2 ± 2 RoA per patient. FA occurred 8 ± 6 times during the 30-second window (cumulative duration 8 ± 6 seconds). RoA occurred 5 ± 3 times (median 2, consecutive rotations) with a cumulative duration of 3 ± 2 seconds. Compared to patients without procedural ...Continue Reading

References

Feb 18, 2010·Circulation. Arrhythmia and Electrophysiology·Karthikeyan UmapathyKumaraswamy Nanthakumar
Apr 16, 2015·Circulation. Arrhythmia and Electrophysiology·Peyman BenharashRavi Mandapati
May 7, 2015·The New England Journal of Medicine·Atul VermaUNKNOWN STAR AF II Investigators
Oct 13, 2016·Circulation. Arrhythmia and Electrophysiology·Brian J HansenVadim V Fedorov
Feb 17, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Sébastien KnechtThomas Rostock
Mar 11, 2017·Journal of the American College of Cardiology·Han S LimMichel Haïssaguerre
Apr 7, 2017·Nature Reviews. Cardiology·Stanley NattelMartin Aguilar
Apr 25, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Aleksandr VoskoboinikJonathan M Kalman
May 10, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Bhupesh PathikJonathan M Kalman
May 17, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hugh CalkinsTeiichi Yamane
Jun 7, 2017·Pacing and Clinical Electrophysiology : PACE·Sergio ContiAtul Verma
Jan 14, 2018·Circulation. Arrhythmia and Electrophysiology·Junaid A B ZamanNicholas S Peters

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Citations

Oct 20, 2018·Journal of Cardiovascular Electrophysiology·Anja SchadeThomas Deneke
Oct 8, 2019·Journal of Cardiovascular Electrophysiology·Tina Baykaner, Junaid A B Zaman
Nov 7, 2019·Journal of Cardiovascular Electrophysiology·Andrea Chiocchini, Atul Verma
Nov 15, 2019·Journal of Cardiovascular Electrophysiology·Yoshihide TakahashiTetsuo Sasano
Dec 13, 2019·Journal of Cardiovascular Electrophysiology·Maria TerricabrasAtul Verma
Jul 8, 2020·Circulation. Arrhythmia and Electrophysiology·Mahmood I AlhusseiniSanjiv M Narayan
Feb 13, 2020·Journal of Cardiovascular Electrophysiology·Gurpreet S DhillonRoss J Hunter
Oct 22, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Andrea ChiocchiniAtul Verma
Nov 11, 2019·Cardiac Electrophysiology Clinics·Dennis H LauPrashanthan Sanders
Feb 23, 2020·JACC. Clinical Electrophysiology·Atul Verma, Sanjiv M Narayan
Nov 7, 2020·Journal of Cardiovascular Electrophysiology·Decebal G LațcuNadir Saoudi
Apr 5, 2021·JACC. Clinical Electrophysiology·Majd E HemamMiguel Valderrábano
May 7, 2021·Journal of Cardiovascular Electrophysiology·Miguel Rodrigo, Sanjiv M Narayan
Jul 24, 2021·JACC. Clinical Electrophysiology·Andrea Sarkozy
Jan 16, 2022·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Yusuke SakamotoMasayoshi Ajioka

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