Characterization and species differences in gastric ghrelin cells from mice, rats and hamsters

Journal of Anatomy
Akira YabukiSyusaku Suzuki

Abstract

Ghrelin is a newly identified gastric peptide hormone that has various important functions, including growth-hormone release and appetite stimulation. Ghrelin-immunoreactive cells (ghrelin cells) are characterized by X-type endocrine cells in the rat stomach. In the present study, we analysed ghrelin cells in fundi of stomach from ICR mice and Syrian hamsters immunohistochemically, immunoelectron microscopically and morphometrically, and compared the results with those from Wistar rats. Immunohistochemistry revealed that ghrelin cells were sparsely distributed in the proper gastric glands in all species. The number of ghrelin cells per unit area in hamsters was significantly lower than that in rats. Immunoelectron microscopy detected ghrelin immunolabelling in granules in the X-type endocrine cells. However, the diameter of granules in the hamsters was significantly smaller than that in the mice and rats. Gastric ghrelin contents were determined by radioimmunoassay, and levels in the hamsters were significantly lower than those in mice and rats. The results from mice were identical to those from rats. In conclusion, gastric ghrelin cells in mice and hamsters are characterized by X-type endocrine cells, as has been observed in r...Continue Reading

Citations

Mar 4, 2006·Histochemistry and Cell Biology·Akira YabukiShusaku Suzuki
Aug 28, 2010·International Journal of Peptides·Ichiro Sakata, Takafumi Sakai
Oct 18, 2011·Metabolism: Clinical and Experimental·Hiroharu MifuneMasayasu Kojima
Apr 14, 2009·Regulatory Peptides·Ichiro SakataJeffrey M Zigman
Nov 26, 2008·Molecular and Cellular Endocrinology·Brandon R MenziesMarilyn B Renfree
Dec 23, 2006·Biochemical and Biophysical Research Communications·Aihua LiAndrzej S Tarnawski
Mar 27, 2009·Microscopy Research and Technique·Nadia ArcamoneFinizia Russo
Aug 23, 2016·The Journal of Clinical Investigation·Bharath K ManiJeffrey M Zigman
Mar 27, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Naokazu HamadaHiroharu Mifune
Mar 25, 2005·Physiological Reviews·Masayasu Kojima, Kenji Kangawa
Apr 29, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter KobeltHubert Mönnikes
Feb 18, 2012·American Journal of Physiology. Endocrinology and Metabolism·Shaji K ChackoAgneta L Sunehag
Nov 6, 2013·Endocrinology·Bharath K ManiJeffrey M Zigman

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