Characterization and stability of solid dispersions based on PEG/polymer blends

International Journal of Pharmaceutics
Heike BleyRoland Bodmeier

Abstract

Solid dispersions were prepared by a melting method from the water-insoluble model drugs carbamazepine and nifedipine and polyethylene glycol 1500 (PEG 1500) or 1:1 mixtures of PEG 1500 and the polymers polyvinylpyrrolidone (PVP 30, PVP 12), polyvinylpyrrolidone-co-vinylacetate (PVPVA) and Eudragit EPO (Eudragit) in order to combine advantages of the different carrier polymers (recrystallization inhibition, processability and stability). The solid dispersions were characterized by dissolution, powder X-ray diffractometry and microscopy directly after preparation and after storage for 3 and 6 months at 25 degrees C/0% relative humidity (RH) or 3 months at 40 degrees C/75% RH. More than 80% drugs were released from all solid dispersions within 20min. The dissolution rate of carbamazepine decreased in the order of PEG 1500>PEG 1500/Eudragit>PEG 1500/PVP 30>PEG 1500/PVPVA>PEG 1500/PVP 12. The dissolution rank order was not directly correlated to the amorphous/crystalline state of the drugs, but rather to the properties of the PEG 1500/polymer compositions. Nifedipine was released in the order of PEG 1500>PEG 1500/PVPVA>PEG 1500/PVP 30>PEG 1500/PVP 12>PEG 1500/Eudragit. Amorphous nifedipine was present in all PEG 1500/polymer disper...Continue Reading

References

Dec 1, 1969·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Aug 1, 1995·Journal of Pharmaceutical Sciences·M YoshiokaG Zografi
Oct 1, 1996·Journal of Pharmaceutical Sciences·L E McMahonP York
Mar 21, 1998·Journal of Pharmaceutical and Biomedical Analysis·R J MarkovichJ Rosen
Mar 11, 1999·Drug Development and Industrial Pharmacy·P MuraP Parrini
Dec 22, 1999·International Journal of Pharmaceutics·Y KobayashiK Yamamoto
Sep 1, 1987·Journal of Pharmaceutical Sciences·M M LowesJ G Van der Watt
Jan 5, 2002·International Journal of Pharmaceutics·Duncan Q M Craig

❮ Previous
Next ❯

Citations

May 11, 2012·Frontiers of Medicine·Liyuan ChenXiguang Chen
Dec 6, 2011·Archives of Pharmacal Research·Ying ChenHong Liu
Jul 10, 2013·International Journal of Nanomedicine·Yan-rong JiangXiao-bin Jia
Jan 1, 2011·International Journal of Pharmaceutical Investigation·B Bindu MadhaviDavid Banji
Jul 27, 2012·Therapeutic Delivery·Otilia M Y Koo, Sailesh A Varia
Sep 15, 2014·International Journal of Pharmaceutics·Bin TianXing Tang
Dec 30, 2011·Drug Development and Industrial Pharmacy·Farnoosh KianfarJoshua S Boateng
Oct 10, 2012·Expert Opinion on Drug Delivery·Mohd Aftab AlamAbdullah M Al-Mohizea
Nov 10, 2015·Expert Opinion on Drug Delivery·Carol A McCarthyAbina M Crean
Jun 13, 2015·Drug Development and Industrial Pharmacy·Djordje P MedarevićSvetlana Ibrić
Feb 4, 2011·Journal of Pharmaceutical Sciences·Parijat KanaujiaReginald B H Tan
Jan 8, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Krisztina NikowitzGéza Regdon
Jun 27, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sofia A PapadimitriouDimitrios N Bikiaris
Nov 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jin LiYong-Qing Fan
Aug 27, 2015·Drug Delivery and Translational Research·Dinesh Kumar MishraPradyumna Kumar Mishra
Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Min Yang, Costas Gogos
Oct 12, 2010·International Journal of Pharmaceutics·Juan J García-RodriguezSantiago Torrado-Santiago
Dec 27, 2011·International Journal of Pharmaceutics·Xiepeng LinHuayue Wu
Jun 8, 2012·Pharmaceutical Development and Technology·Silvina G CastroSantiago D Palma
Jun 20, 2014·Pharmaceutical Development and Technology·Milica VukićevićHanne Hjorth Tønnesen
Oct 3, 2013·International Journal of Pharmaceutics·Yasser ShahzadSyed Nisar Hussain Shah
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chau Le-Ngoc VoBeom-Jin Lee
Mar 10, 2016·Journal of Advanced Pharmaceutical Technology & Research·Alexander V GerasimovLiana S Usmanova
Sep 7, 2016·International Journal of Pharmaceutics·Choon Lian NgJeong-Sook Park
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Samixa DesaiKrutika Sawant
Sep 4, 2018·Pharmaceutical Development and Technology·Rahul V HawareWilliam C Stagner
May 17, 2019·Therapeutic Delivery·Alicia Graciela CidJosé María Bermúdez
Dec 1, 2017·International Journal of Pharmaceutical Investigation·Gada Sulaiman A AlagdarBappaditya Chatterjee
Feb 22, 2017·Journal of Advanced Pharmaceutical Technology & Research·Liana Stanislavovna UsmanovaAlexander Vladimirovich Gerasimov
Aug 14, 2019·AAPS PharmSciTech·Nitin SalunkhePrafulla Choudhari
Oct 27, 2017·Pharmaceutical Development and Technology·Ahmed H IbrahimAhmed M Samy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved