PMID: 9025Jul 1, 1976

Characterization and tissue distribution of N-acetyl hexosaminidase C: suggestive evidence for a separate hexosaminidase locus

Annals of Human Genetics
D M SwallowH Harris


1. An electrophoretic system in which N-acetyl hexosaminidase C (HEX(C)) MIGRATES LESS ANODALLY THAN N-acetyl hexosaminidase A (HEX(A)) is described. 2. HEX(C) is shown to differ from HEX(A) and HEX(B) in substrate specificity, molecular size and affinity for Concanavalin-A. 3. HEX(C) is present in a wide range of adult and foetal tissues and in tissues from patients with Tay-Sachs and Sandhoff's diseases. It is particularly prominent in brain, testis, thymus and lymphoblastoid cell extracts and in several foetal tissues. 4. It is suggested that HEX(C) is coded at a separate gene locus from HEX(A) and HEX(B).


May 23, 1975·Biochimica Et Biophysica Acta·E PentonJ C Dreyfus
Oct 1, 1973·Archives of Disease in Childhood·E M BrettR Stephens
Nov 1, 1974·The Biochemical Journal·I BraidmanD Robinson
May 26, 1972·Biochemical and Biophysical Research Communications·S K Srivastava, E Beutler
Feb 12, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Poenaru, J C Dreyfus
Jan 1, 1974·Annals of Human Genetics·D M SwallowH Harris
May 1, 1974·FEBS Letters·I BraidmanG J Hooghwinkel
Mar 1, 1972·Archives of Biochemistry and Biophysics·D W Darnall, I M Klotz


Mar 1, 1981·The Histochemical Journal·G Huether, V Neuhoff
Oct 7, 1977·Molecular and Cellular Biochemistry·M Wan HoJ S O'Brien
Jul 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·C H Lo, D Kritchevsky
Jan 1, 1989·The International Journal of Biochemistry·T BeccariA Orlacchio
Jan 1, 1991·The International Journal of Biochemistry·T BeccariA Orlacchio
Jun 22, 1987·Biochimica Et Biophysica Acta·M HardyL Douste-Blazy
Oct 8, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·L F PérezJ C Tutor
Feb 1, 1981·Annals of Human Genetics·D M SwallowD W Buck
Oct 1, 1977·Annals of Human Genetics·E Beutler, W Kuhl
Aug 15, 1977·Experientia·H E Müller
Jan 1, 1979·Folia Microbiologica·N A Hegazi, K Vlassak
Jan 1, 1982·Antonie van Leeuwenhoek·M R Betlach
May 1, 1982·Antonie van Leeuwenhoek·E Wilde, H G Schlegel
Oct 23, 2014·The Journal of Biological Chemistry·Jana AlonsoDaan M F van Aalten

Related Concepts

Genome Mapping
Concanavalin A
Electrophoresis, Starch Gel
Fetal Structures
Hydrogen-Ion Concentration
Isoelectric Point

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