PMID: 6167545Sep 1, 1980Paper

Characterization, evolution, and molecular basis of a polymorphic antigenic determinant shared by HLA-A and B products

Human Immunology
P Parham, J McLean

Abstract

In our search for monoclonal antibodies defining specific HLA-A,B antigens we have found a significant number of antibodies with polymorphic reactions that are not explicable with our current picture of HLA-A,B interrelationships. Analysis of one antibody (MB40.1) in some detail shows that it recognizes subsets of both A and B antigens and that it is able to split highly cross-reactive pairs of A or B antigens. These results address an outstanding difference in the serological interpretation of H-2, where these types of public reactions have been well established, from HLA, where they have been poorly characterized. Comparison of these types of serological reactions with amino acid sequence data and the apparent evolutionary stability of these broad cross-reacting determinants suggests a simple model for the molecular nature based upon limited amino acid variability and convergent evolution.

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Citations

Dec 1, 1980·Human Immunology·B D SchwartzG E Rodey
Oct 1, 1981·Human Immunology·F M BrodskyP Parham
Aug 1, 1982·Human Immunology·R V RouseI L Weissman
Aug 1, 1982·Human Immunology·F C GrumetE G Engleman
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J A López de CastroH T Orr
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L M SmithH M McConnell
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A ZeeviR J Duquesnoy
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J YamamotoM Takiguchi
Apr 17, 2014·British Medical Bulletin·Kelley M K Haarberg, Anat R Tambur
Feb 13, 2016·Frontiers in Immunology·Michelle J HickeyElaine F Reed
Oct 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J CaiL Rebellato
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·C M Zmijewski
Oct 1, 1983·Tissue Antigens·S MinamiT Takahashi
Oct 1, 1983·Tissue Antigens·M H BreuningP Iványi

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