Characterization of 19A-like 19F pneumococcal isolates from Papua New Guinea and Fiji

New Microbes and New Infections
E M DunneJ Hinds

Abstract

Molecular identification of Streptococcus pneumoniae serotype 19F is routinely performed by PCR targeting the wzy gene of the capsular biosynthetic locus. However, 19F isolates with genetic similarity to 19A have been reported in the United States and Brazil. We screened 78 pneumococcal carriage isolates and found six 19F wzy variants that originated from children in Papua New Guinea and Fiji. Isolates were characterized using multilocus sequence typing and opsonophagocytic assays. The 19F wzy variants displayed similar susceptibility to anti-19F IgG antibodies compared to standard 19F isolates. Our findings indicate that these 19F variants may be more common than previously believed.

References

Sep 12, 2007·Bioinformatics·M A LarkinD G Higgins
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Sep 2, 2011·Journal of Clinical Microbiology·Eileen M DunneCatherine Satzke
May 25, 2012·Vaccine·UNKNOWN WHO Publication
Jun 14, 2012·Journal of Clinical Microbiology·Lotta SiiraAnni Virolainen
May 10, 2013·Journal of Clinical Microbiology·Ana Paula de O MenezesBernard Beall

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Citations

Jan 22, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Laura M A OliveiraLucia M Teixeira
Nov 13, 2020·Reports of Biochemistry & Molecular Biology·Mehrdad MosadeghMohammad Azarsa

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Methods Mentioned

BETA
PCR

Software Mentioned

ClustalW

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