Characterization of 33 488 children and adolescents with type 1 diabetes based on the gender-specific increase of cardiovascular risk factors

Pediatric Diabetes
K Otfried SchwabDPV Science Initiative and the Competence Network Diabetes mellitus

Abstract

Characterization of children with type 1 diabetes (T1DM) regarding number and gender distribution of cardiovascular risk factors (cvRF) and of total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C ratio) for risk assessment. 33488 patients <or=18 years were included in this cross-sectional analysis and placed into 5 categories by their number of cvRF. Dyslipidemia (TC >200 mg/dL, >5.17 mmol/L; and/or HDL-C <35 mg/dL, <0.91 mmol/L; and/or LDL-C >130 mg/dL, >3.36 mmol/L), elevated systolic and/or diastolic blood pressure (BP) >or=90th percentile, obesity >97th percentile, active smoking, and HbA1c >or=7.5% were considered as cvRF. 65% had no or 1 cvRF. HbA1c >/=7.5% was the most frequently occurring cvRF followed by BP >or=90th percentile, dyslipidemia, smoking, and BMI >97th percentile. Age at diabetic onset ranged from 7.7 to 9.2 years and diabetes duration from 4.1 to 6.6 years. CvRF showed differences in disfavour of females except smoking and HDL-C <35 mg/dL (0.91 mmol/L). Rate of females was 45% with 0 cvRF and 60% with 4 to 5 cvRF. TC/HDL-C ratio showed no clear association to the number of cvRF. 35% of a pediatric T1DM population develops 2 or more cvRF thus increasing their cv risk in adulthood. With inc...Continue Reading

References

Feb 1, 1991·Journal of Hypertension·S A de ManA Hofman
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·S P LaingH Keen
Nov 4, 2000·The American Journal of Clinical Nutrition·H C McGillJ P Strong
Jan 29, 2002·Diabetes·Mikko J JärvisaloOlli T Raitakari
Jul 9, 2002·Computer Methods and Programs in Biomedicine·Matthias GrabertReinhard W Holl
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Annamaria ColaoGaetano Lombardi
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Shengxu LiGerald S Berenson
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Olli T RaitakariJorma S A Viikari
Oct 14, 2004·The Journal of Pediatrics·Jody S KrantzFrancine R Kaufman
Apr 11, 2006·Preventive Cardiology·Ana Marice LadeiaArmênio C Guimarães
Oct 4, 2006·Pediatrics·C Alex McMahanUNKNOWN Pathobiological Determinants of Atherosclerosis in Youth Research Group
Jan 24, 2007·The Journal of Pediatrics·David M MaahsGeorgeanna J Klingensmith
Feb 7, 2007·Archives of Pediatrics & Adolescent Medicine·Diana B PetittiUNKNOWN SEARCH for Diabetes in Youth Study Group
May 22, 2007·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·W ThierfelderC Scheidt-Nave
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Erik IngelssonRamachandran S Vasan
Jan 16, 2008·Diabetologia·H D MargeirsdottirUNKNOWN Norwegian Study Group for Childhood Diabetes
Dec 23, 2008·International Journal of Adolescent Medicine and Health·Karl Otfried SchwabKarl Winkler

❮ Previous
Next ❯

Citations

Feb 22, 2011·Current Diabetes Reports·Kristen J Nadeau, Jane E B Reusch
Apr 25, 2012·Journal of Cardiovascular Translational Research·Janet K Snell-Bergeon, Kristen Nadeau
May 7, 2014·Current Diabetes Reports·Petter Bjornstad, R Paul Wadwa
Apr 8, 2016·Journal of Diabetes and Its Complications·Ulf SamuelssonLena Hanberger
Feb 19, 2015·Diabetes Care·Tilman R RohrerUNKNOWN DPV Initiative and the German BMBF Competence Network Diabetes Mellitus
May 16, 2014·Canadian Journal of Diabetes·Diane WherrettDanièle Pacaud
Sep 13, 2014·International Journal of Endocrinology·Włodzimierz LuczyńskiArtur Bossowski
Oct 17, 2014·Thrombosis and Haemostasis·S TehraniA Antovic
Apr 16, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SilvestriG A Rossi
Mar 28, 2013·International Journal of Hypertension·Marilia B GomesLuis Henrique Canani
Sep 13, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·L Golmayo GazteluR Barrio Castellanos
Feb 4, 2014·The Journal of Pediatrics·K Otfried SchwabUNKNOWN German/Austrian Diabetes Documentation and Quality Management System (DPV) and the German Health Interview and Examination S
Feb 10, 2018·International Journal of Hypertension·Mohsen JanghorbaniMasoud Amini
Oct 18, 2018·Current Diabetes Reports·Petter Bjornstad, Robert H Eckel
Apr 20, 2012·Drugs·Marjet J A M BraamskampAlbert Wiegman
Apr 12, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·I KosteriaUNKNOWN SWEET study group
Dec 21, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Tuba BulutAyşe Metin
May 9, 2014·Archives of Disease in Childhood·Elke E Fröhlich-ReitererUNKNOWN DPV-Wiss Study Group and German BMBF Competence Networks Diabetes mellitus and Obesity
Sep 4, 2014·Pediatric Diabetes·Włodzimierz ŁuczyńskiUNKNOWN PolPeDiab Polish Research Group
Jun 26, 2020·Frontiers in Endocrinology·Lara E Graves, Kim C Donaghue
Jun 22, 2019·Journal of Diabetes Research·Ingrida StankuteRasa Verkauskiene
Jul 16, 2020·International Journal of Molecular Sciences·Ida PastorePaolo Fiorina
Jun 24, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Eda Celebi BitkinHasan Murat Aydın

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

Pediatric Diabetes
Nicole S GlaserLawson Wilkins Pediatric Endocrine Society Committee on Drugs and Therapeutics
Diabetes Research and Clinical Practice
Giuliana ValerioStudy-Group on Diabetes of Italian Society of Pediatric Endocrinology and Diabetology (ISPED)
The Journal of Clinical Endocrinology and Metabolism
Peter O Kwiterovich
© 2021 Meta ULC. All rights reserved