Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats

British Journal of Pharmacology
Y Nishimura

Abstract

1. The 5-hydroxytryptamine (5-HT) induced-contraction in ring preparations of basilar arteries from Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) was pharmacologically characterized in vitro. 2. Contractile responses to 5-HT (1 nM-100 nM) and their pD2 values in arteries from SHRSP at 6 months of age were significantly greater than those in age-matched WKY, although the maximum response did not differ between the two groups. 3. There were no significant differences in contractile responses to U-44619, endothelin-1, neuropeptide Y, and angiotensin II between WKY and SHRSP arteries. 4. Spiperone (1 nM-1 microM, a 5-HT2 receptor antagonist), produced biphasic displacement of the 5-HT curves in WKY and SHRSP arteries. The response to high concentrations of 5-HT was concentration-dependently antagonized by spiperone, while the response to low concentrations of 5-HT was resistant to blockade by spiperone, and the spiperone-resistant contractile responses induced by 5-HT were greater in SHRSP than in WKY. Ketanserin (1-100 nM, 5-HT2) also produced a biphasic shift of the 5-HT curves for both arteries. 5. Methiothepin (10 and 100 nM, 5-HT1 and 5-HT2) potently inhibited 5-HT-induced contractions in bot...Continue Reading

References

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Citations

Oct 17, 2008·Neurocritical Care·S SalomoneJohn Randall Sims
Feb 1, 1997·Clinical and Experimental Pharmacology & Physiology·Y Nishimura, A Suzuki
Mar 13, 2012·Pharmacological Reviews·Stephanie W WattsSusan M Barman
Jul 23, 2008·Neuropharmacology·Antoinette MaassenVanDenBrinkCarlos M Villalón
Jun 5, 2012·European Journal of Pharmacology·Anikó KovácsGábor Szénási
Apr 21, 2004·Cephalalgia : an International Journal of Headache·U ReuterC Waeber
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·Takanari KitazonoMasatoshi Fujishima
May 4, 2010·Cardiovascular Therapeutics·Stephanie W Watts, Robert Patrick Davis
Apr 16, 2005·Clinical Science·Stephanie W Watts
Apr 7, 2004·Journal of Biomedical Science·Chern-En ChiangHsiang-Ning Luk

Related Concepts

Metazoa
Structure of Basilar Artery
Dose-Response Relationship, Drug
R-41,468
Methiothepin
Inotropism
Muscle, Smooth, Vascular
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Tryptamine

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