Characterization of a cDNA clone encoding pedal peptide in the terrestrial snail

Neuroreport
D A PoteryaevA V Belyavsky

Abstract

We report the isolation of a Helix lucorum cDNA clone encoding a precursor of neuropeptides that are closely related to Aplysia and Tritonia pedal peptides (Pep). The predicted propeptide contains 20 copies of the two variants of Helix Pep interspersed with Lys-Arg endopeptidase cleavage sites. Northern blot hybridization revealed multiple Pep-hybridizing species in the Helix CNS RNA. The Pep gene was expressed by several identified serotonergic neurones in pedal and cerebral ganglia, groups of sensory neurones in procerebrum, peripheral neurones in olfactory bulb, mantle and foot, and group of neurones in pedal ganglia presumably involved in locomotion control. Pep mRNA was detected in several neurones at the early stages of nervous system development.

Citations

Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yvette WilsonMark Murphy
Apr 12, 2011·PloS One·Pavel M BalabanRichard Boyle
Mar 1, 2011·General and Comparative Endocrinology·Tibor Kiss
Aug 30, 2005·The Journal of Comparative Neurology·Galina A Pavlova, A O Dennis Willows
Oct 12, 2018·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Galina A Pavlova
Oct 16, 2019·Scientific Reports·T L DyakonovaV E Dyakonova

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