PMID: 6170061Jul 1, 1981Paper

Characterization of a class of cationic proteins that specifically interact with intermediate filaments

Proceedings of the National Academy of Sciences of the United States of America
P M SteinertB A Dale

Abstract

We describe a class of cationic structural proteins that associate specifically with intermediate filaments (IF) but not with other types of cytoskeletal proteins. These proteins, for which the term filaggrin is introduced, are isolated from the stratum corneum of mammalian epidermis. They are species-distinct proteins; for example, rat and mouse filaggrin have different molecular weights and amino acid compositions, but are nevertheless chemically and functionally ver similar. They interact in vitro with the IF several different types of cells to form large fibers or macrofibrils in which many IF are highly aligned in parallel arrays. Stoichiometric analyses suggest that two molecules of filaggrin bind to each three-chain building block of the IF, possibly by ionic interactions with the coiled-coil alpha-helical regions of the IF.

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Citations

Jan 1, 1990·Cell Motility and the Cytoskeleton·K D Brown, L I Binder
Jan 1, 1995·Cell Motility and the Cytoskeleton·A Brown, R J Lasek
Jan 1, 1987·Archives of Dermatological Research·J Mansbridge, M Knapp
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Aug 7, 2009·Journal of Biochemistry·Rumi GoharaShoji Ando

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