Characterization of a distinct subpopulation of striatal projection neurons expressing the Dlx genes in the basal ganglia through the activity of the I56ii enhancer

Developmental Biology
Noël GhanemMarc Ekker

Abstract

Regulation of region-specific neuronal differentiation and migration in the embryonic forebrain is a complex mechanism that involves a variety of transcription factors such as the Dlx genes. At least four cis-acting regulatory elements (CREs) are responsible for the Dlx transcriptional regulation in the subcortical telencephalon and the rostral diencephalon. These include I12b and URE2 in the Dlx1/2 bigene cluster, and, I56i and I56ii in the Dlx5/6 cluster. We previously reported that URE2, I12b, and I56i, mark different progenitor cell populations in the ganglionic eminences as well as different subtypes of adult cortical interneurons. Here, we carried out a detailed spatial and temporal analysis of the I56ii CRE activity in the developing telencephalon between E10.5 and E15.5, and compared its activity with the other three Dlx CREs using lacZ reporter genes in transgenic mice. We show that I56ii marks distinct group(s) of neurons located in the superficial mantle of the LGE and MGE between E11.5 and E13.5. The I56ii-positive cells are Dlx- and GABA-immunoreactive. However, unlike the other CREs, I56ii does not label interneuron progenitors in the basal ganglia, nor tangentially migrating cells to the cortex at E13.5. Instead,...Continue Reading

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Citations

Aug 24, 2012·Human Molecular Genetics·Ramon Y BirnbaumNadav Ahituv
Jul 5, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Man YuMarc Ekker
Apr 6, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez
Aug 14, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dorothea Schulte, Dale Frank
May 9, 2015·Human Molecular Genetics·Di WuAnne M Slavotinek
Apr 30, 2013·Current Biology : CB·Ludmilla LokmaneSonia Garel
Oct 18, 2011·Current Biology : CB·Franck BielleGuillermina López-Bendito
Jul 11, 2013·PloS One·Mélanie Debiais-ThibaudDidier Casane
Aug 1, 2016·Neuroscience and Biobehavioral Reviews·Elliot Murphy, Antonio Benítez-Burraco
Sep 14, 2016·Frontiers in Neuroscience·Antonio Benítez-BurracoElliot Murphy
Jan 1, 2014·Neurogenesis·Dorothea Schulte
Nov 1, 2016·Nature Neuroscience·Jordane DimidschsteinGord Fishell
Nov 9, 2018·Frontiers in Psychology·Elliot Murphy, Antonio Benítez-Burraco
Feb 23, 2011·Developmental Biology·Steven Q IrvineRachel E Holbert

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