Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation

Differentiation; Research in Biological Diversity
B C PowellA Nesci

Abstract

Many different cysteine-rich proteins are synthesized during hair follicle differentiation, forming part of the interstitial matrix between bundles of intermediate filaments. We have isolated a rabbit gene (rKAP4L), a member of a multigene family that encodes a small cysteine-rich hair keratin associated protein. This is the first complete gene sequence for this family. The rKAP4L gene is expressed in the cortex of rabbit pelage hair follicles at a late stage of hair follicle differentiation, well after the synthesis of the other major hair proteins, the intermediate filament and glycine/tyrosine-rich keratin associated proteins, has commenced. The protein contains 36 mol % cysteine, with a molecular size of 13593 daltons, and its sequence appears to be based on a pentapeptide repeat. It is predicted to adopt a folded conformation characterized by beta-turns interspersed with short stretches of beta-sheet or random coil.

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Citations

Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Yutaka ShimomuraMasaaki Ito
Feb 3, 2012·International Journal of Biological Sciences·Hua GongJonathan G H Hickford
Nov 6, 1998·The Journal of Investigative Dermatology·N AokiM Ito
Nov 6, 1998·The Journal of Investigative Dermatology·K KizawaH Uchiwa
Feb 14, 2002·The Journal of Investigative Dermatology·Yutaka ShimomuraMasaaki Ito
Dec 31, 1997·The Journal of Biological Chemistry·N AokiM Ito
Sep 14, 2002·The Journal of Biological Chemistry·Yutaka ShimomuraMasaaki Ito
Jan 5, 2002·Physiological Genomics·N E CockettM Smit

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