Abstract
Many different cysteine-rich proteins are synthesized during hair follicle differentiation, forming part of the interstitial matrix between bundles of intermediate filaments. We have isolated a rabbit gene (rKAP4L), a member of a multigene family that encodes a small cysteine-rich hair keratin associated protein. This is the first complete gene sequence for this family. The rKAP4L gene is expressed in the cortex of rabbit pelage hair follicles at a late stage of hair follicle differentiation, well after the synthesis of the other major hair proteins, the intermediate filament and glycine/tyrosine-rich keratin associated proteins, has commenced. The protein contains 36 mol % cysteine, with a molecular size of 13593 daltons, and its sequence appears to be based on a pentapeptide repeat. It is predicted to adopt a folded conformation characterized by beta-turns interspersed with short stretches of beta-sheet or random coil.
References
Feb 1, 1992·Molecular Biology Reports·E TobiaschH Winter
Mar 1, 1990·The Journal of Investigative Dermatology·A P BertolinoD W Yu
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A R McNabG Vogeli
Dec 1, 1990·The Journal of Cell Biology·P J MacKinnonG E Rogers
Jan 1, 1991·Electron Microscopy Reviews·R C MarshallJ M Gillespie
Dec 26, 1991·Annals of the New York Academy of Sciences·B C PowellG E Rogers
Feb 1, 1989·The Journal of Investigative Dermatology·A R McNabG Vogeli
Feb 1, 1989·Genomics·M J FrenkelG E Rogers
Feb 25, 1985·Nucleic Acids Research·J McLauchlanJ B Clements
Jan 11, 1982·Nucleic Acids Research·M I Kanehisa
Aug 25, 1983·Nucleic Acids Research·B C PowellG E Rogers
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Feb 1, 1994·The Journal of Investigative Dermatology·A FratiniG E Rogers
May 1, 1994·The Journal of Investigative Dermatology·N HuhT Kuroki
Jun 1, 1994·Experimental Cell Research·H WinterJ Schweizer
Sep 1, 1994·The Journal of Investigative Dermatology·B J Jenkins, B C Powell
Jul 1, 1993·The Journal of Investigative Dermatology·G E Rogers, B C Powell
Citations
Apr 3, 1998·Gene·S MitsuiH Ogawa
Aug 5, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Yutaka ShimomuraMasaaki Ito
Aug 30, 2008·BMC Evolutionary Biology·Dong-Dong WuYa-Ping Zhang
Feb 3, 2012·International Journal of Biological Sciences·Hua GongJonathan G H Hickford
Sep 12, 2014·BMC Genomics·Imran KhanAgostinho Antunes
Nov 6, 1998·The Journal of Investigative Dermatology·N AokiM Ito
Jul 17, 1998·The Journal of Investigative Dermatology·M TakaishiN Huh
Nov 6, 1998·The Journal of Investigative Dermatology·K KizawaH Uchiwa
Feb 14, 2002·The Journal of Investigative Dermatology·Yutaka ShimomuraMasaaki Ito
Jul 8, 2016·Asian-Australasian Journal of Animal Sciences·Mei JinJing'ai Piao
Dec 31, 1997·The Journal of Biological Chemistry·N AokiM Ito
Mar 30, 2001·The Journal of Biological Chemistry·M A RogersJ Schweizer
Sep 14, 2002·The Journal of Biological Chemistry·Yutaka ShimomuraMasaaki Ito
Jan 5, 2002·Physiological Genomics·N E CockettM Smit
Oct 3, 2002·The Journal of Biological Chemistry·Michael A RogersJürgen Schweizer