PMID: 11931465Apr 5, 2002Paper

Characterization of a high-dose-rate 90Sr-90Y source for intravascular brachytherapy by using the Monte Carlo code PENELOPE

Physics in Medicine and Biology
J AsenjoA Sánchez-Reyes

Abstract

Radiation treatment with catheter-based beta-emitter sources is currently under clinical trial to prevent restenosis. In the present paper, we address the characterization of the high-dose-rate 90Sr-90Y seeds of the Beta-Cath system supplied by Novoste Corporation, one of the commercially available sources for intravascular brachytherapy. The Monte Carlo code PENELOPE has been used to simulate the transport of electrons emitted by the encapsulated 90Sr-90Y seeds. The calculated radial dose function and anisotropy function for a single seed in water are compared with simulation results from other authors. Regarding g(r), the present result lies between the ITS3 and EGS4 curves, being somewhat closer to ITS3, while in the case of F(r, theta) some differences appear for certain angular intervals and radial distances. In order to put the observed differences into perspective, we have calculated radial doses for point isotropic sources in water. Our results for 0.5 and 1 MeV electrons are in good agreement with simulations using EGSnrc, and an excellent agreement is obtained with ITS for point 90Sr-90Y emitters. Dose distributions in water are calculated for source 'trains' consisting of 1, 2, 3, 4, 5, 9 and 12 seeds. The dose at th...Continue Reading

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Citations

Oct 8, 2003·Medical Physics·E Leticia RojasPedro Galán
Oct 7, 2006·Medical Physics·Shannon M HolmesJohn A Micka
Sep 15, 2009·Medical Physics·Y PrezadoA Bravin
Dec 10, 2009·Medical Physics·Y PrezadoA Bravin
Apr 5, 2016·The British Journal of Radiology·Junxiang WuChengjun Gou
Jan 4, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Jae Won Jung, Warren Daniel Reece

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