Characterization of a high-voltage-activated IA current with a role in spike timing and locomotor pattern generation

Proceedings of the National Academy of Sciences of the United States of America
D Hess, Abdeljabbar El Manira

Abstract

Transient A-type K+ channels (I(A)) in neurons have been implicated in the delay of the spike onset and the decrease in the firing frequency. Here we have characterized biophysically and pharmacologically an I(A) current in lamprey locomotor network neurons that is activated by suprathreshold depolarization and is specifically blocked by catechol at 100 microM. The biophysical properties of this current are similar to the mammalian Kv3.4 channel. The role of the I(A) current both in single neuron firing and in locomotor pattern generation was analyzed. The I(A) current facilitates Na+ channel recovery from inactivation and thus sustains repetitive firing. The role of the I(A) current in motor pattern generation was examined by applying catechol during fictive locomotion induced by N-methyl-d-aspartate. Blockade of this current increased the locomotor burst frequency and decreased the firing of motoneurons. Although an alternating motor pattern could still be generated, the cycle duration was less regular, with ventral roots bursts failing on some cycles. Our results thus provide insights into the contribution of a high-voltage-activated I(A) current to the regulation of firing properties and motor coordination in the lamprey sp...Continue Reading

References

Jun 1, 1988·Neuroscience·B Rudy
Sep 23, 1988·Neuroscience Letters·L Erdélyi, G Such
Feb 1, 1971·The Journal of Physiology·J A Connor, C F Stevens
Dec 1, 1981·Acta Physiologica Scandinavica·S GrillnerM Wilén
Jul 1, 1996·Physiological Reviews·E Marder, R L Calabrese
May 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·H InokuchiR L Meckler
Oct 6, 1997·Journal of Neurophysiology·A El Manira, N Bussières
Jul 4, 1998·Brain Research. Brain Research Reviews·S GrillnerP Wallén
Jul 22, 1999·Annals of the New York Academy of Sciences·W A CoetzeeB Rudy
Jul 22, 1999·Annals of the New York Academy of Sciences·B RudyE Vega-Saenz de Miera
Nov 26, 1999·Nature Neuroscience·N E Schoppa, G L Westbrook
Jan 15, 2000·Progress in Brain Research·R Delgado-Lezama, J Hounsgaard

❮ Previous
Next ❯

Citations

May 24, 2006·Brain Research·Desheng Wang, Bernard G Schreurs
Feb 19, 2003·Brain Research. Brain Research Reviews·Sten Grillner, Peter Wallén
Dec 20, 2002·Current Opinion in Neurobiology·Ronald M Harris-Warrick
Dec 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Evanthia NanouAbdeljabbar El Manira
Jan 15, 2004·Molecular Pharmacology·Elena Zaks-MakhinaEdwin S Levitan
Oct 14, 2011·Journal of Neurophysiology·Tatiana M AndersonMark A Masino
Apr 20, 2011·The Journal of Physiology·Jesper EricssonSten Grillner
Jun 26, 2004·The European Journal of Neuroscience·B Lamotte D'IncampsA El-Manira
Aug 2, 2003·British Journal of Pharmacology·Ulrike BischoffAndrea Olschewski
Feb 8, 2007·The European Journal of Neuroscience·Evanthia Nanou, Abdeljabbar El Manira
Jun 8, 2006·Biochemical and Biophysical Research Communications·Na ChenJin-Hui Wang
May 9, 2006·Biochemical and Biophysical Research Communications·Sudong GuanJin-Hui Wang
Dec 14, 2005·Biochemical and Biophysical Research Communications·Na ChenJinhui Wang
Aug 23, 2005·Trends in Neurosciences·Maria Toledo-RodriguezJørn Hounsgaard
Dec 25, 2016·The Journal of Experimental Biology·Charlotte L BarkanDarcy B Kelley
Jul 3, 2003·Nature Reviews. Neuroscience·Sten Grillner
Feb 8, 2003·Journal of Neurophysiology·Robert R BussPierre Drapeau
Oct 6, 2006·Journal of Neurophysiology·David Parker, Sarah Bevan
Feb 9, 2007·Journal of Neurophysiology·Mikael HussJeanette H Kotaleski
Mar 3, 2007·Journal of Neurophysiology·Dietmar HessAbdeljabbar El Manira
Nov 6, 2009·Journal of Neurophysiology·Evanthia Nanou, Abdeljabbar El Manira
Sep 4, 2015·Physiology·Aklesso KadalaArlette Kolta
Aug 2, 2006·The Journal of Pharmacology and Experimental Therapeutics·Vicenta Salvador-RecatalaEdwin S Levitan
Jul 11, 2012·The European Journal of Neuroscience·Crawford I P Winlove, Alan Roberts
Sep 14, 2018·Nature Communications·Charles PetitpréFrançois Lallemend

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.