PMID: 3124340Dec 1, 1987Paper

Characterization of a homogeneous paraprotein from a horse with spontaneous multiple myeloma syndrome

Veterinary Immunology and Immunopathology
R K SeideJ M Kehoe

Abstract

A novel myeloma paraprotein has been isolated from a horse with a lymphoid tumor. The protein was a euglobulin and consequently was readily isolated from serum in pure form and high yield by simple dilution in distilled water. The purified intact protein had a molecular weight of 150,000 and was composed of heavy and light chains, both of which had blocked amino-termini and were thus not susceptible to amino-terminal sequence analysis. The amino acid compositions of these respective chains corresponded to those of comparable chains from immunoglobulins of other species. Peptide maps of paraprotein light chains prepared by high pressure liquid chromatography corresponded in part to those of normal pooled equine light chains. The identification of this paraprotein as an equine AI (aggregating immunoglobulin) protein was confirmed by serological analysis using a specific antiserum. The relationship of this particular protein to other members of the immunoglobulin family was further demonstrated by the production of an anti-idiotypic antiserum individually specific for this molecule.

References

Nov 1, 1985·Equine Veterinary Journal·J Traub-DargatzS M Roberts
Jul 1, 1974·Equine Veterinary Journal·R A Drew, J C Greatorex
Aug 1, 1983·Kidney International·P SmolensJ H Stein
Sep 1, 1983·Veterinary Pathology·R M JacobsW W Ruoff
Jan 1, 1982·The Journal of Small Animal Practice·J W Finnie, C R Wilks
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·F WienerH Bazin

Citations

Jul 1, 1995·Veterinary Immunology and Immunopathology·B WagnerW Leibold
Oct 14, 2010·Equine Veterinary Journal. Supplement·K J Hughes

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