PMID: 2115670Jul 11, 1990Paper

Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif

Nucleic Acids Research
S A LiebhaberN E Cooke

Abstract

A human term placental cDNA library was screened at low stringency with a human prolactin cDNA probe. One of the cDNAs isolated hybridizes to a 1.8 kb mRNA present in all four tissues of the placenta as well as to every nucleated tissue and cell line tested. The sequence of the full-length cDNA was determined. An extended open reading frame predicted an encoded protein product of 20.5 kDa. This was directly confirmed by the in vitro translation of a synthetic mRNA transcript. Based upon the characteristic placement of cysteine (C) and histidine (H) residues in the predicted protein structure, this molecule contains four putative zinc fingers. The first and third fingers are of the C4 class while the second and fourth are of the C2HC class. Based upon sequence similarities between the first two and last two zinc fingers and sequence similarities to a related rodent protein, cysteine-rich intestinal protein (CRIP), these four finger domains appear to have evolved by duplication of a preexisting two finger unit. Southern blot analyses indicate that this human cysteine-rich protein (hCRP) gene has been highly conserved over the span of evolution from yeast to man. The characteristics of this protein suggest that it serves a fundame...Continue Reading

References

Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A M Maxam, W Gilbert
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·G N WilsonR D Schmickel
Sep 16, 1976·Nature·N J Proudfoot, G G Brownlee
Aug 1, 1976·European Journal of Biochemistry·H R Pelham, R J Jackson
Jun 26, 1989·Nucleic Acids Research·A MazenG de Murcia
Jun 1, 1989·The Journal of Clinical Investigation·S A LiebhaberN E Cooke
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H Birkenmeier, J I Gordon
Jan 15, 1988·Cell·R M Evans, S M Hollenberg
Jun 3, 1988·Cell·A D Frankel, C O Pabo
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P S HenthornH Harris
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L A Schuler, W L Hurley
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D P GiedrocJ E Coleman
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P K VogtR F Doolittle
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D I LinzerD Nathans
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Mar 1, 1983·Endocrinology·J ClementsJ Funder

❮ Previous
Next ❯

Citations

Jan 29, 2002·Journal of Cellular Biochemistry·Enders Kai On NgKwok Pui Fung
Jun 1, 1994·Nature Structural Biology·G C Pérez-AlvaradoM F Summers
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J W MichelsenD R Winge
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·V E ArcherT H Rabbitts
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·R FeuersteinS A Liebhaber
Dec 1, 1992·The Journal of Cell Biology·I SadlerM C Beckerle
Sep 1, 1996·The Journal of Cell Biology·B E StronachM C Beckerle
Apr 9, 2009·Cardiovascular Research·Luciene Cristina Gastalho CamposJose Eduardo Krieger
Dec 1, 1992·The Plant Cell·R BaltzA Steinmetz
Aug 13, 2010·Development·George DialynasLori L Wallrath
Jun 1, 1992·Molecular Reproduction and Development·I B DawidM R Rebagliati
Feb 18, 2003·Cell Motility and the Cytoskeleton·James R HendersonMary C Beckerle
Feb 14, 2002·The Journal of Investigative Dermatology·Ellen J van der GaagH Randolph Byers
Apr 27, 2010·Photodermatology, Photoimmunology & Photomedicine·Leena LatonenMarikki Laiho
Dec 29, 1998·Mechanisms of Development·J M Delalande, P Y Rescan
Jan 18, 2003·Developmental Cell·David F ChangRobert J Schwartz
Jan 27, 2004·FEBS Letters·Markus Grubinger, Mario Gimona
Mar 25, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J R HendersonM C Beckerle
May 2, 1997·The Journal of Biological Chemistry·R KonratK Bister
Dec 1, 1995·The Journal of Biological Chemistry·R WeiskirchenM C Beckerle
Feb 17, 2005·Journal of Cell Science·Joo-ri Kim-KaneyamaMotoko Shibanuma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.