Characterization of a human homologue of proteolysis-inducing factor and its role in cancer cachexia

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Constance L MonittoDavid Sidransky

Abstract

Cachexia is an important cause of secondary morbidity and mortality in patients with cancer. Previous studies have suggested that cancer-associated cachexia may be due in part to tumor-specific production and secretion of a glycosylated peptide, proteolysis-inducing factor, originally identified in a murine cancer cachexia model. We report here the cloning of a human cDNA that generates a peptide having high-sequence homology to this proteolysis-inducing factor. Constitutive expression of human proteolysis-inducing factor is low or absent in most normal human tissues but appears to be elevated in some human tumors. Stable forced expression of human proteolysis-inducing factor in multiple murine and human cell lines results in a secreted protein, but no glycosylation of the protein is detected. In addition, tumor xenografts engineered to overexpress human proteolysis-inducing factor protein do not induce cachexia in vivo. These findings raise important questions as to potential cross-species differences in protein sequence and processing of murine proteolysis-inducing factor and human proteolysis-inducing factor, as well as the nature of the relationship between human proteolysis-inducing factor and the development of cancer cac...Continue Reading

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Citations

Apr 11, 2006·Annual Review of Nutrition·Vickie E Baracos
Mar 30, 2012·Journal of Innate Immunity·Birgit Schittek
Jun 28, 2014·BMC Research Notes·Marina MikhaylovaMichael R Kreutz
Jul 16, 2011·Gastroenterology Research and Practice·Claire L DonohoeJohn V Reynolds
Apr 24, 2007·Biochemical and Biophysical Research Communications·Jin-Pyo Lee MotoyamaKenji Suzuki
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Aug 6, 2020·Cancer Management and Research·Jun Ni, Li Zhang
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara M WielandVickie E Baracos

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