PMID: 8581742Jun 30, 1995Paper

Characterization of a mouse recA-like gene specifically expressed in testis

DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes
S SatoS Tabata

Abstract

Using the sequence information on a class of recA-like genes, which have been isolated from meiosis-specific cDNA libraries of Lilium and budding yeast and identified in various plant cells, a new gene was screened from a mouse testis cDNA library. The putative product of the gene, termed MmLim15, was 37.8 kDa consisting of 340 amino acid residues. The predicted amino acid sequence showed 72-78% similarity to those of Lim15 from Lilium and other meiosis-specific RecA-like proteins. Similarity was also found to another class of recA-like proteins, Rad51 and its homologues, which have been detected in both budding and fission yeasts and various animal cells, but to a lesser extent and the similarity patterns were somewhat different from those for Lim15 type proteins, revealing that the two classes of recA-like genes are phylogenetically separate. Reverse transcription-PCR using poly(A)+ RNAs from various tissues as templates indicated that transcription of MmLim15 occurred specifically in the testis, suggesting that the MmLim15 product participates in meiotic recombination.

Citations

Jul 10, 1998·Biochimica Et Biophysica Acta·M Kawabata, K Saeki
Jan 12, 2011·Journal of Experimental Botany·Bernd Edlinger, Peter Schlögelhofer
Mar 10, 2000·Nucleic Acids Research·F Hartung, H Puchta
Jan 2, 2008·European Journal of Endocrinology·Béatrice Mandon-PépinMarc Fellous
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z LiC M Radding
Nov 18, 2005·Molecular and Biochemical Parasitology·Chris Proudfoot, Richard McCulloch
Aug 15, 1998·The Journal of Biological Chemistry·D K BishopA Shinohara

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