PMID: 3754176Jan 1, 1986Paper

Characterization of a new primary human pancreatic tumor line

Cancer Investigation
M H TanT M Chu

Abstract

A primary human pancreatic tumor line (BxPC-3) has been established from a biopsy specimen of a histologically confirmed adenocarcinoma of the body of the pancreas. Tumorigenicity was proven by xenograft in athymic nude mice. Upon re-establishment of tumor xenografts in tissue culture, the epithelial tumor cells retained their original morphology. Histopathologically, the tumors grown in nude mice exhibited the original characteristics of the primary adenocarcinoma in the patient, producing traceable mucin and displaying moderately well to poorly differentiated adenocarcinomas with occasional lymphocytic infiltrations at the tumor peripheries. Furthermore, the tumor xenografts differentially expressed carcinoembryonic antigen, human pancreas cancer-associated antigen, and human pancreas-specific antigen. Karyotyping and glucose-6-phosphate dehydrogenase isoenzyme characterization revealed that this tumor line was of human origin and devoid of HeLa cell contamination. The BxPC-3 tumor line has been maintained for more than four years in our laboratory and represents a valuable model for primary human pancreatic cancer.

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Citations

Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·I El-HariryN R Lemoine
Mar 1, 2000·Biochemical and Biophysical Research Communications·J KoikeM Katoh
Apr 25, 2000·Biochemical and Biophysical Research Communications·H KirikoshiM Katoh
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Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y ShibamotoM Tsujitani
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·David AzriaAndré Pèlegrin
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ville BisterUlpu Saarialho-Kere
Jan 11, 2013·The Journal of Biological Chemistry·Nehal GosaliaAnn Harris
Apr 27, 2010·Pancreas·Emily L DeerSean J Mulvihill
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Sep 14, 2010·Journal of Biomedical Science·Xiaojun LiuShen Hu
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