Characterization of a nose-only inhalation exposure system for hydrocarbon mixtures and jet fuels

Inhalation Toxicology
Sheppard A MartinJeffrey W Fisher

Abstract

A directed-flow nose-only inhalation exposure system was constructed to support development of physiologically based pharmacokinetic (PBPK) models for complex hydrocarbon mixtures, such as jet fuels. Due to the complex nature of the aerosol and vapor-phase hydrocarbon exposures, care was taken to investigate the chamber hydrocarbon stability, vapor and aerosol droplet compositions, and droplet size distribution. Two-generation systems for aerosolizing fuel and hydrocarbons were compared and characterized for use with either jet fuels or a simple mixture of eight hydrocarbons. Total hydrocarbon concentration was monitored via online gas chromatography (GC). Aerosol/vapor (A/V) ratios, and total and individual hydrocarbon concentrations, were determined using adsorbent tubes analyzed by thermal desorption-gas chromatography-mass spectrometry (TDS-GC-MS). Droplet size distribution was assessed via seven-stage cascade impactor. Droplet mass median aerodynamic diameter (MMAD) was between 1 and 3 mum, depending on the generator and mixture utilized. A/V hydrocarbon concentrations ranged from approximately 200 to 1300 mg/m(3), with between 20% and 80% aerosol content, depending on the mixture. The aerosolized hydrocarbon mixtures rema...Continue Reading

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Citations

Oct 6, 2010·Toxicology Mechanisms and Methods·G JoshiJ W Fisher
Dec 23, 2011·Inhalation Toxicology·Sheppard A MartinJeffrey W Fisher
Jan 13, 2011·Inhalation Toxicology·Raphael T TremblayJeffrey W Fisher
Jan 13, 2011·Inhalation Toxicology·Zhe Zhang, Clement Kleinstreuer
Apr 26, 2013·Inhalation Toxicology·Lisa M SweeneyJames E Reboulet
Mar 12, 2010·Inhalation Toxicology·Raphael T TremblayJeffrey W Fisher

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