Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway.

Molecular and Cellular Biology
A Nakai, R I Morimoto

Abstract

We have cloned three avian heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and the avian homologs of mammalian HSF1 and HSF2. The predicted amino acid sequence of HSF3 is approximately 40% related to the sequence of HSF1 and HSF2. The sequences for all three factors exhibit extensive identify in the DNA binding motifs and the heptad repeats of hydrophobic amino acids which are common to all eukaryotic HSFs. Despite these overall similarities, each avian HSF exhibits distinct DNA binding properties. HSF2 when expressed in vitro binds constitutively to the heat shock element promoter sequence, whereas neither HSF1 nor HSF3 expressed in vitro binds to DNA. HSF1 DNA binding is induced upon heat shock or treatment with nonionic detergents, whereas the DNA binding properties of HSF3 are not induced by these conditions in vitro. These results suggest that HSF3 activation may involve an induction pathway distinct from the traditional forms of heat shock gene induction. HSF3 DNA binding activity, however, is obtained when the carboxyl-terminal region including the distal heptad repeat is deleted, indicating the presence of negative cis-regulatory sequences. The HSF3 message, like HSF1 and HSF2 messages...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 2, 1992·Nature·M J Gething, J Sambrook
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S K RabindranC Wu
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T J SchuetzR E Kingston
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M M MillerC G Miyada
Mar 7, 1991·Biochimica Et Biophysica Acta·J Garcia-BustosM N Hall
Apr 15, 1991·Biochemical and Biophysical Research Communications·A NakaiK Nagata
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D D MosserR I Morimoto
Jan 1, 1989·Annual Review of Biochemistry·P F Johnson, S L McKnight
Jan 1, 1988·Annual Review of Genetics·S Lindquist, E A Craig
Sep 30, 1988·Science·M F BarbeW J Welch
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies

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Citations

Oct 15, 2010·The FEBS Journal·Mitsuaki Fujimoto, Akira Nakai
Oct 15, 2010·The FEBS Journal·Ryma Abane, Valérie Mezger
Sep 3, 2005·Immunological Investigations·Ashish NagarsekarIshwar S Singh
Aug 14, 2001·Blood Cells, Molecules & Diseases·J TanikawaS Ishii
Dec 15, 2010·Biochemistry Research International·Anastasis Stephanou, David S Latchman
May 25, 2002·European Journal of Biochemistry·Martine ManuelMichel Morange
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·M RalluV Mezger
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·K KaarnirantaH J Helminen
Sep 25, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Hajar KhosravanianNarges Khosravanian
Jan 7, 2000·Journal of Molecular Biology·J A HardyH C Nelson
Jun 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·M Locke, E G Noble
Jan 10, 2002·Critical Care Medicine·Elisabeth S ChristiansIvor J Benjamin
Dec 25, 2003·Molecular Reproduction and Development·Nadja Suzana Mogyca LeandroMarcos Macari
Oct 30, 2009·Molecular Biology of the Cell·Mitsuaki FujimotoAkira Nakai
Apr 12, 2000·Journal of Gastroenterology and Hepatology·K Rokutan
Oct 3, 1999·European Journal of Biochemistry·Y KawazoeA Nakai
Sep 11, 2002·Cell Structure and Function·Shohko KunimotoKimiko Murakami-Murofushi
Oct 1, 1995·Plant Molecular Biology·E Czarnecka-VernerW B Gurley
Aug 26, 2003·Journal of Cellular Biochemistry·Bo ShiRonald B Gartenhaus
Sep 18, 1998·Molecular Reproduction and Development·D E MuscarellaS E Bloom
Apr 25, 2012·Cell Stress & Chaperones·Cynthia L SwanPatrick H Krone

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