Characterization of a Novel HIV-1 CRF01_AE/CRF07_BC Recombinant Virus Among Men Who Have Sex with Men in Tianjin, China

AIDS Research and Human Retroviruses
Zhangwen GeYiming Shao

Abstract

We report here a novel human immunodeficiency virus type 1 (HIV-1) second-generation recombinant form comprising CRF01_AE and CRF07_BC isolated from an HIV-positive male subject infected among men who have sex with men (MSM) in Tianjin in north China. The phylogenetic analysis of the near full-length genome of TJIH0345 reveals that three regions of CRF01_AE were inserted into the CRF07_BC backbone with five recombinant breakpoints observed in the pol, vif, vpu, and env gene regions whose genome structure is distinctly different from other circulating recombinant forms and unique recombinant forms previously reported. The continued emergence of the novel recombinant strain in Tianjin, China, highlights the increasing complexity of the HIV-1 epidemic among the MSM population, and further molecular epidemiological investigation should be done to track the genetic evolution of HIV-1 strains to prevent HIV transmission.

References

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Jun 8, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lin LiJingyun Li
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May 5, 2018·AIDS Research and Human Retroviruses·Zhehua ZhouMin Wei

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Citations

Apr 11, 2020·Journal of Medical Virology·Wei LiPingmin Wei

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Methods Mentioned

BETA
PCR

Software Mentioned

SimPlot3
Sequencher
jpHMM
FastTree
SimPlot

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