Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain

Cancer Research
Koji KawakamiRaj K Puri

Abstract

The interleukin (IL)-13 receptor alpha2 (IL-13Ralpha2) chain is a primary binding and internalization subunit for a Th2-derived immune regulatory cytokine, IL-13. Although extremely high levels of IL-13Ralpha2 chain are expressed on a variety of human tumor cells and specimens, its precise role in tumor immunology has not been defined. To investigate the role of IL-13Ralpha2 in tumor immunity, we used D5 melanoma cells stably transfected with the human IL-13Ralpha2 gene (D5alpha2) to assess the effect of an IL-13Ralpha2 DNA vaccine in immunocompetent animals. Prophylactic immunization of mice with the IL-13Ralpha2 DNA vaccine resulted in protection against D5alpha2 tumor development. In vivo depletion experiments in C57BL/6 and RAG-2 knockout mice indicated that both T and B cells, but not natural killer cells, were required for the tumor protection. In addition, antibody induced by the IL-13Ralpha2 DNA vaccine showed a modest but significant inhibitory effect on D5alpha2 cells in vitro, suggesting that the antibody is biologically functional. The IL-13Ralpha2 DNA vaccine also exhibited antitumor activity against established D5alpha2 tumors in mice. Histologic analysis of regressing tumors identified infiltration of CD4+ and CD...Continue Reading

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Citations

Aug 5, 2008·Cancer Immunology, Immunotherapy : CII·Wenqiao YuYanjun Zeng
Aug 19, 2007·Current Allergy and Asthma Reports·Yasuhiro Tabata, Gurjit K Khurana Hershey
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Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Koji KawakamiRaj K Puri
May 20, 2021·Scientific Reports·Lachlan P DeimelCharani Ranasinghe

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