PMID: 9537385Apr 16, 1998Paper

Characterization of a novel member of the DegS-DegU regulon affected by salt stress in Bacillus subtilis

Journal of Bacteriology
V DartoisG Rapoport

Abstract

As a soil bacterium also found in estuarine and marine habitats, Bacillus subtilis has evolved various sensing and adaptation systems in order to face salt stress conditions. Among these regulatory mechanisms is the DegS-DegU signal transduction system, which was previously shown to be stimulated by high salt concentrations. A search for promoters regulated in response to salt stress led to the identification of wapA, encoding a wall-associated protein, which is strongly expressed at low salt concentrations and almost completely repressed in the presence of 0.7 M disodium succinate. Repression of wapA transcription by salt stress was shown to require the phosphorylated form of DegU. Moreover, DegU-mediated repression of wapA occurred only in high-salt medium. Alignment between the control region of wapA and other DegU-regulated promoters allowed the identification of a putative DegU target sequence, AGAAN(11)TTCAG. Mutation/deletion analyses of the wapA promoter region confirmed the role of the putative DegU control site in repression of wapA transcription at high salt concentrations and revealed a second site of repression located downstream from the transcription start site. Since residual negative control was observed at thi...Continue Reading

References

Oct 1, 1992·Journal of General Microbiology·U VölkerM Hecker
Jul 1, 1992·Journal of Bacteriology·J P Mueller, A L Sonenshein
Dec 1, 1991·Gene·O Arantes, D Lereclus
Sep 1, 1991·Microbiological Reviews·D Dubnau
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J B Perkins, P J Youngman
Nov 1, 1994·Journal of Bacteriology·S RiethdorfM Hecker
Feb 1, 1996·Molecular Microbiology·M HeckerU Völker

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Citations

Jan 16, 2002·Journal of Bacteriology·Tamara HoffmannErhard Bremer
Sep 11, 2007·Applied and Environmental Microbiology·Alexandra KoumoutsiRainer Borriss
Jan 16, 2008·FEMS Microbiology Letters·Kensuke Tsukahara, Mitsuo Ogura
Dec 25, 2009·FEMS Microbiology Reviews·Daniel López, Roberto Kolter
Aug 16, 2013·Environmental Microbiology·Che-Man ChanAgnieszka Sekowska
Jul 13, 2004·The Journal of Biological Chemistry·Larisa E CybulskiDiego de Mendoza
Mar 28, 2002·Applied and Environmental Microbiology·Ophélie DuchéJean Labadie
Sep 8, 2010·Molecular Microbiology·Taryn B Kiley, Nicola R Stanley-Wall
Apr 17, 2008·Molecular Systems Biology·Jan-Willem VeeningOscar P Kuipers
Jul 20, 2010·Journal of Bacteriology·Diana WolfThorsten Mascher
Jun 21, 2002·Acta Microbiologica Et Immunologica Hungarica·K SzarkaA Repkény
May 28, 2017·Applied and Environmental Microbiology·Kazuo KobayashiHirofumi Yoshikawa
Jul 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·L W HamoenD Dubnau
May 1, 1999·Applied and Environmental Microbiology·S McGrathD van Sinderen
Jul 23, 2005·Microbiological Research·Leila GabdrakhmanovaInna Leshchinskaya

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