PMID: 2120155Aug 1, 1990Paper

Characterization of a novel Minute-locus in Drosophila melanogaster: a putative ribosomal protein gene

Heredity
S Andersson, Andrew Lambertsson

Abstract

We describe a novel Minute locus, M(1)7C, on the X-chromosome of Drosophila melanogaster. Heterozygous deficient females have most, if not all, of the Minute features (short and fine bristles, rough and somewhat larger eyes, thin-textured wings, missing aristae, affected antennae, delayed development, reduced fertility, and decreased viability). Both Minute and non-Minute adult progeny from Minute mothers suffer from Minute maternal effects such as abdominal segmentation defects, fused tergites, and missing or defective legs and halteres. Using a plasmid clone from region 7C5-9, which harbours the D. melanogaster ribosomal protein gene RPS14, we have found that the accumulation of a single transcript of approximately 650 b is extremely reduced in Minute larvae in comparison with wild-type. We have localized the RPS14 gene to approximately 28 kbp distal from the singed locus. The results suggest that M(1)7C and RPS14 may be the same gene.

References

Jan 1, 1989·Hereditas·L Hansson, A Lambertsson
Jun 1, 1985·Biochemical Genetics·V K Walker
Oct 10, 1985·Nature·K KongsuwanJ Merriam
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M A Muskavitch, D S Hogness

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Citations

Nov 25, 2000·British Journal of Haematology·C A SieffD G Nathan
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K L WatsonP J Bryant
Mar 30, 2007·Molecular Biology of the Cell·Zhengfang Cui, Patrick J DiMario
Mar 4, 2000·Current Opinion in Hematology·T N WilligC A Sieff
Sep 1, 2006·British Journal of Haematology·Hanna T Gazda, Colin A Sieff
Feb 15, 2005·Biochemical and Biophysical Research Communications·Sang Hwa KimJoon Kim
Feb 15, 2000·International Reviews of Immunology·F W Chen, Y A Ioannou

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