Characterization of a novel model of tonic heat pain stimulation in healthy volunteers

Pain
Arne L G NaertRon Kupers

Abstract

The vast majority of the experimental pain studies have used acute, phasic heat stimuli to investigate the neurobiological mechanisms of pain. However, the validity of these models for understanding clinical forms of pain is questionable. We here describe the characteristics of a model of prolonged tonic heat pain stimulation and compared the responses on this test with other measures of pain. In 58 normal volunteers, we applied a 7-min lasting contact heat stimulation of 47 degrees C to the upper leg while participants constantly rated their pain. Average pain rating during the 7-min period was 6.2+/-0.4, females scoring higher than men (7.4+/-0.5 vs. 5.2+/-0.5; p<0.005). Pain ratings showed a steady increase during the first half of the stimulation period after which they stabilized. A strong interindividual variability was observed in the time profiles of the pain ratings over the course of the 7-min stimulation period. The model showed a good test-retest reproducibility. Tonic heat pain ratings only correlated moderately with the pain threshold while stronger correlations were observed with pain tolerance and ratings of suprathreshold phasic heat pain. We conclude that the tonic heat model is a suitable model that can be ap...Continue Reading

References

Jun 22, 1992·Neuroscience Letters·A V ApkarianF D Thomas
Jul 1, 1991·Pain·M al Absi, P D Rokke
Feb 1, 1989·American Journal of Physical Medicine & Rehabilitation·N E WalshJ Hoffman
Jul 1, 1981·British Journal of Pharmacology·S E Carpenter, B Lynn
Sep 1, 1984·Experimental Neurology·A KrehH O Handwerker
Jan 1, 1995·Somatosensory & Motor Research·S LautenbacherF Strian
Apr 1, 1994·Brain : a Journal of Neurology·S KiloH O Handwerker
Mar 31, 1999·The Behavioral and Brain Sciences·K J Berkley
Dec 22, 1999·Pain·J L Rhudy, M W Meagher
May 29, 2002·Pain·Eleni Sarlani, Joel D Greenspan
Jul 6, 2002·Pain·Karen D Davis, Geoffrey E Pope
Feb 26, 2003·European Journal of Pain : EJP·Michal GranotDavid Yarnitsky
Jun 14, 2003·Gastroenterology·Bruce D NaliboffEmeran A Mayer
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert C CoghillYi-Fen Yen
Nov 5, 2003·British Journal of Health Psychology·Jack E James, Drifa Hardardottir
May 12, 2004·Neuroscience Letters·Ilkka K MartikainenAntti Pertovaara
Sep 28, 2004·Basic & Clinical Pharmacology & Toxicology·Camilla Staahl, Asbjørn Mohr Drewes
Sep 6, 2005·The Journal of Pain : Official Journal of the American Pain Society·Judy Tang, Stephen J Gibson
Jan 21, 2006·Hormones and Behavior·Anna Maria Aloisi, Marco Bonifazi
Mar 11, 2006·Pain·Till SprengerThomas R Tölle
Oct 24, 2006·Nature Medicine·Irmgard TegederClifford J Woolf

❮ Previous
Next ❯

Citations

Oct 12, 2012·Journal of Pain Research·Pernille RavnMads U Werner
Aug 11, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Keren ReinerJoshua Dan Lipsitz
Apr 11, 2012·International Journal of Hygiene and Environmental Health·Marie Thi Dao TranJesper Elberling
Mar 5, 2015·Acta Anaesthesiologica Scandinavica·V M RasmussenM U Werner
Jun 17, 2015·The Journal of Pain : Official Journal of the American Pain Society·Shu ZhouAndré Dufour
Jul 28, 2009·Pain·Javeria A Hashmi, Karen D Davis
Dec 6, 2016·Cephalalgia : an International Journal of Headache·Martin UglemTrond Sand
Jun 28, 2020·Cerebral Cortex·Andrew J FurmanDavid A Seminowicz
Oct 7, 2017·European Journal of Pain : EJP·R C PriceP Schweinhardt
Aug 20, 2019·The Journal of Pain : Official Journal of the American Pain Society·Roland StaudMichael E Robinson
Oct 17, 2020·Journal of Pain Research·Ines DaguetGuillaume Leonard
Feb 17, 2021·The Journal of Obstetrics and Gynaecology Research·Diana KantarovichKevin M Hellman
Jul 31, 2021·PloS One·Anders Deichmann SpringborgMads Utke Werner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved