Characterization of a novel nanobiomaterial fabricated from HA, TiO2 and Al2 O3 powders: an in vitro study

Progress in Biomaterials
Mahboobeh MahmoodiRana Imani

Abstract

For the purposes of this study, hydroxyapatite (HA)-Al2O3-TiO2 nanobiomaterial with significant surface properties and biocompatibility capable of forming surface apatite was fabricated by cold-press and sintering method. Samples were examined for hardness and porosity. The results showed that in terms of hardness and porosity, sample A (50 wt% TiO2-30 wt% HA-20 wt% Al2O3) was superior to sample B (30 wt% TiO2-50 wt% HA-20 wt% Al2O3), and also the density of nanobiomaterial was close to natural bone density. Bioactivity of the samples in a simulated body fluid (SBF) was investigated. Then, after immersing the samples in SBF solution for a period of 7 days, sample B exhibited greater ability to form calcium phosphate compounds on the surface as compared to sample A. In addition, in vitro studies showed that MG-67 osteoblast-like cells attached and spread on the samples surface. The results showed that cells proliferated in greater numbers on the sample B as compared to the sample A. Finally, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray analysis were performed to identify phases, study microstructure, and determine percentage of elements, respectively. The results revealed that considering their di...Continue Reading

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