Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo.

The Journal of Biological Chemistry
Hui FengC S Rubin

Abstract

Protein kinase D (PKD) isoforms are protein kinase C (PKC) effectors in diacylglycerol (DAG)-regulated signaling pathways. Key physiological processes are placed under DAG control by the distinctive substrate specificity and intracellular distribution of PKDs. Comprehension of the roles of PKDs in homeostasis and signal transduction requires further knowledge of regulatory interplay among PKD and PKC isoforms, analysis of PKC-independent PKD activation, and characterization of functions controlled by PKDs in vivo. Caenorhabditis elegans and mammals share conserved signaling mechanisms, molecules, and pathways Thus, characterization of the C. elegans PKDs could yield insights into regulation and functions that apply to all eukaryotic PKDs. C. elegans DKF-1 (D kinase family-1) contains tandem DAG binding (C1) modules, a PH (pleckstrin homology) domain, and a Ser/Thr protein kinase segment, which are homologous with domains in classical PKDs. DKF-1 and PKDs have similar substrate specificities. Phorbol 12-myristate 13-acetate (PMA) switches on DKF-1 catalytic activity in situ by promoting phosphorylation of a single amino acid Thr(588) in the activation loop. DKF-1 phosphorylation and activation are unaffected when PKC activity is...Continue Reading

References

Jan 1, 1989·Annual Review of Biochemistry·U KikkawaY Nishizuka
Jun 10, 1988·Science·C Kenyon
Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M ValverdeE Rozengurt
Sep 1, 1995·Medicinal Research Reviews·G S KroogJ F Battey
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C SavageR W Padgett
Jan 10, 1997·The Journal of Biological Chemistry·K NishikawaL C Cantley
Aug 8, 1997·The Journal of Biological Chemistry·S A MatthewsE Rozengurt
Sep 1, 1997·Nature Genetics·G JansenR H Plasterk
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·S HarbinderM Driscoll
Feb 7, 1998·The Journal of Biological Chemistry·T Iglesias, E Rozengurt
Jun 26, 1998·The Biochemical Journal·H Mellor, P J Parker
Oct 9, 1998·The Journal of Biological Chemistry·T IglesiasE Rozengurt
Nov 6, 1998·Nature·L Timmons, A Fire
Apr 21, 1999·Current Opinion in Cell Biology·N Moghal, P W Sternberg
May 8, 1999·Biochimica Et Biophysica Acta·A HayashiT Saito
Jun 4, 1999·Progress in Biophysics and Molecular Biology·C M SmithS S Taylor
Aug 4, 1999·Trends in Genetics : TIG·M Labouesse, S E Mango
Aug 26, 1999·Trends in Genetics : TIG·A Fire
Jan 19, 2000·Trends in Genetics : TIG·G I Patterson, R W Padgett
Mar 4, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D KoyaR Kikkawa
Jun 19, 2001·The Journal of Biological Chemistry·R T WaldronE Rozengurt
Jan 5, 2002·The Journal of Cell Biology·Angelika HausserFranz-Josef Johannes
Apr 30, 2002·Trends in Cell Biology·Johan Van LintThomas Seufferlein
Dec 10, 2002·Science·G ManningS Sudarsanam
Dec 18, 2002·Journal of Neurobiology·Oliver Hobert
Dec 24, 2002·The Biochemical Journal·Alexandra C Newton
Feb 4, 2003·Nature Reviews. Drug Discovery·Chris J VlahosAngela Clerk

❮ Previous
Next ❯

Citations

Nov 26, 2008·The Journal of Biological Chemistry·Vitalyi O RybinSusan F Steinberg
Jun 27, 2007·BMC Developmental Biology·Dieter MaierAnette Preiss
Apr 29, 2008·BMC Developmental Biology·Kornelia EllwangerAngelika Hausser
Jan 5, 2013·IUBMB Life·Kornelia Ellwanger, Angelika Hausser
May 18, 2016·Cell Reports·Mehran NajibiJavier Elbio Irazoqui
Apr 15, 2006·The Journal of Biological Chemistry·Hui FengCharles S Rubin
May 31, 2019·G3 : Genes - Genomes - Genetics·Dieter MaierAnette Preiss
Sep 18, 2021·Molecular Pharmacology·Susan F Steinberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.