Characterization of a phenotypically and functionally distinct subset of large granular lymphocytes (pit cells) in rat liver sinusoids

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K VanderkerkenE Wisse

Abstract

Pit cells, or large granular lymphocytes, with natural tumoricidal activity are found in the sinusoids of normal rat liver. Hepatic large granular lymphocytes are heterogeneous and can be subdivided into two subsets. These subsets were compared with peripheral-blood large granular lymphocytes and were found to differ phenotypically and functionally. Phenotypical differences included lower expression of the asialo-GM1 marker of natural killer cells, lower cellular density and many more small cytoplasmic granules in hepatic large, granular lymphocytes. Low-density hepatic large, granular lymphocytes were five to eight times more cytotoxic than blood large, granular lymphocytes on a per-cell basis as measured against YAC-1 cells and colon carcinoma cells. In addition, hepatic large, granular lymphocytes were able to lyse P-815 target cells, which are resistant to blood natural killer cells. Large, granular lymphocytes isolated from the liver also contained a subset with intermediate phenotypical and functional characteristics, possibly representing a transitional form between blood and "liver-specific" large, granular lymphocytes. The liver thus contains a specific population of highly activated or further differentiated large gra...Continue Reading

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Citations

Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D VermijlenE Wisse
Jul 25, 2013·Journal of Autoimmunity·Kelly HudspethDomenico Mavilio
Jul 1, 1996·Journal of Hepatology·K P de JongO T Terpstra
Oct 7, 2000·Journal of Gastroenterology and Hepatology·T TsukishiroA Watanabe
Aug 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M TerabeK Yokomuro
May 8, 1998·Microbiology and Immunology·M ShirachiK Tanikawa
Feb 13, 2004·Comparative Hepatology·Sergiusz DurowiczWaldemar L Olszewski
Sep 4, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shoko KimuraNoriko Murase
Jun 8, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Li-Hong LvYun-Le Wan
Dec 8, 2015·Cellular & Molecular Immunology·Hui PengZhigang Tian
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Makoto OchiToshimasa Asahara
Jun 12, 2010·Immunological Reviews·Silke PaustUlrich H von Andrian
Feb 1, 1994·Journal of Pediatric Surgery·H IshizuG Arya
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K VanderkerkenE Wisse
Jun 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D LuoE Wisse
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K VanderkerkenE Wisse
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriM Tanaka
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HataT L Whiteside
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K VanderkerkenE Wisse
Jan 1, 1996·Toxicologic Pathology·W C Hall, J L Rojko
Jan 1, 1996·Toxicologic Pathology·E WisseA Vermoesen
May 2, 2007·Journal of Leukocyte Biology·Charles C CaldwellAlex B Lentsch
Aug 30, 2005·World Journal of Gastroenterology : WJG·Katrien Vekemans, Filip Braet
Feb 1, 1992·Liver·L Bouwens, E Wisse

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