Characterization of a point mutation in the parC gene of Mycoplasma bovirhinis associated with fluoroquinolone resistance

Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
K HiroseH Sato

Abstract

Quinolone-resistant (QR) mutants of Mycoplasma bovirhinis strain PG43 (type strain) were generated by stepwise selection in increasing concentrations of enrofloxacin (ENR). An alteration was found in the quinolone resistance-determining region (QRDR) of the parC gene coding for the ParC subunit of topoisomerase IV from these mutants, but not in the gyrA, gyrB, and parE gene coding for the GyrA and GyrB subunits of DNA gyrase and the ParE subunit of topoisomerase IV. Similarly, such an alteration in QRDR of parC was found in the field isolates of M. bovirhinis, which possessed various levels of QR. The substitution of leucine (Leu) by serine (Ser) at position 80 of QRDR of ParC was observed in both QR-mutants and QR-isolates. This is the first report of QR based on a point mutation of the parC gene in M. bovirhinis.

References

Sep 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·A ShimadaY Yamane
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·R J Reece, A Maxwell
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·H YoshidaS Nakamura
Oct 20, 1987·Journal of Molecular Biology·S L Swanberg, J C Wang
Apr 16, 1966·The Veterinary Record·P S DawsonC T McCrea
Oct 1, 1982·Nihon juigaku zasshi. The Japanese journal of veterinary science·M OgataK Yamamoto
Jan 1, 1993·Drugs·E Cambau, L Gutmann
Dec 1, 1993·Journal of Bacteriology·S N PetersonC A Hutchison
Apr 1, 1996·Antimicrobial Agents and Chemotherapy·H KobayashiK Yamamoto
Nov 15, 1996·Nucleic Acids Research·R HimmelreichR Herrmann
Feb 1, 1997·Antimicrobial Agents and Chemotherapy·C M BebearJ Renaudin
Aug 4, 1998·Antimicrobial Agents and Chemotherapy·C M BébéarJ Renaudin
May 23, 2001·Nucleic Acids Research·I ChambaudA Blanchard
Jul 19, 2001·The Journal of Veterinary Medical Science·K HiroseH Ogawa
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·S RaherisonC M Bébéar
Oct 11, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·K HiroseH Sato

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Citations

Oct 24, 2007·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·J ViccaF Haesebrouck
Apr 25, 2013·Antimicrobial Agents and Chemotherapy·I LysnyanskyS Levisohn
Jun 29, 2010·International Journal of Antimicrobial Agents·Yasushi ShimadaHiroaki Ishiko
Nov 23, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Kazuhiro KawaiToshio Oshida
May 21, 2016·Frontiers in Microbiology·Inna Lysnyansky, Roger D Ayling

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