PMID: 2494348Mar 1, 1989Paper

Characterization of a polymorphism in the 3' part of the chicken vitellogenin gene

Journal of Molecular Evolution
J N PhilipsenG AB

Abstract

An allele giving rise to a polymorphism within the 3' part of the chicken vitellogenin gene was cloned, sequenced, and compared to the previously cloned allele. The polymorphism is formed by a perfect copy of 343 bp from intron 32 in tandem array with a perfect copy of 244 bp from intron 33; this 587-bp element is inserted in a head-to-tail arrangement in intron 33. We propose a mechanism in which an unequal crossing-over resulted in a vitellogenin gene with two exons 33, one of which was subsequently deleted. Thus, intron 33 was enlarged by the tandem repeats without affecting the protein-encoding sequence of the gene. At the boundaries of the repeated elements, two short direct repeats are found that resemble the recombination signals of immunoglobulin genes. They may have had a key role in the formation of the new allele.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 18, 1985·Biochimica Et Biophysica Acta·J N PhilipsenG Ab
Mar 17, 1986·European Journal of Biochemistry·J A LenstraW Möller
Jul 24, 1981·Nucleic Acids Research·A C ArnbergA B Geert
Apr 14, 1983·Nature·S Tonegawa
Nov 15, 1983·Journal of Molecular Biology·A M FrischaufN Murray
Feb 1, 1980·Cell·A C ArnbergP Borst

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