Characterization of a population of tyrosine hydroxylase-containing interneurons in the external plexiform layer of the rat olfactory bulb

Neuroscience
T LiberiaC Crespo

Abstract

The olfactory bulb (OB) of mammals contains the major endogenous dopamine-producing system in the forebrain. The vast majority of dopaminergic neurons consists of juxtaglomerular cells, which innervate the olfactory glomeruli and modulate the entrance of sensory information to the OB. Although dopaminergic juxtaglomerular cells have been widely investigated, the presence of dopaminergic interneurons other than juxtaglomerular cells has been largely unexplored. In this study, we analyze a population of tyrosine hydroxylase (TH)-containing interneurons located in the external plexiform layer (EPL) of the rat OB. These interneurons are GABAergic and morphologically heterogeneous. They have an axon and two to four dendrites running throughout the EPL. Frequently, they have appendages similar to spines in the dendrites and, sometimes, the distal portions of the dendritic branches show enlargements or swellings similar to varicosities. Contrary to other interneurons of the EPL, the TH-containing ones do not form dendro-dendritic synapses on principal cells and do not receive dendro-dendritic synapses from them. In fact, no synapses were found from the dendrites of these interneurons. When their dendrites are involved in synaptic cont...Continue Reading

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Citations

May 22, 2016·Brain Research Bulletin·Moses B EkongDaniel A Friday
Aug 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carlos CrespoEmilio Varea
Mar 7, 2017·Frontiers in Neuroanatomy·Angela Pignatelli, Ottorino Belluzzi

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