PMID: 2495536Apr 1, 1989Paper

Characterization of a presecretory phase in B-cell differentiation

Proceedings of the National Academy of Sciences of the United States of America
L B King, R B Corley

Abstract

We have identified and characterized an inducible in vitro subclone of the CH12 B-cell lymphoma, CH12-LBK, which appears to represent a transitional phase in the B-cell differentiation pathway. This phase, which we call the "presecretory" phase, falls between replicating B cells that are not secreting antibodies and B cells that secrete antibody at a high rate. Presecretory cells are characterized by abundant steady-state levels of immunoglobulin and joining (J) chain transcripts and of protein but low levels of mouse mammary tumor virus envelope transcripts and low rates of immunoglobulin secretion. Additional stimulation is required for presecretory cells to differentiate into cells that secrete antibodies at a high rate. The existence of cells with this phenotype suggests that high-level expression of immunoglobulin and J-chain protein does not necessarily commit a B cell to polymerize and secrete multimeric immunoglobulin. Rather, other gene products, expressed after immunoglobulin and J-chain transcripts have been upregulated late in B-cell differentiation, appear responsible for inducing high rates of antibody secretion.

References

Jan 1, 1985·Annual Review of Immunology·M E Koshland
Apr 1, 1985·The Journal of Experimental Medicine·E E Max, S J Korsmeyer
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R B CorleyG Haughton
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J D CongerG J Nossal
Sep 1, 1974·The Journal of Experimental Medicine·J AnderssonD Stott
Jun 1, 1970·The Journal of Experimental Medicine·T TakahashiE A Boyse
Sep 1, 1984·The Journal of Experimental Medicine·G Lamson, M E Koshland
Jul 1, 1981·The Journal of Experimental Medicine·J M McCuneH G Kunkel
Jan 1, 1982·Journal of Cellular Biochemistry·F MelchersJ Zeuthen
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G M CannM E Koshland

❮ Previous
Next ❯

Citations

Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T D RandallR B Corley
Nov 1, 1990·The Journal of Experimental Medicine·A J Feeney
Dec 1, 1991·The Journal of Experimental Medicine·F E Lund, R B Corley
Dec 2, 2004·Journal of Autoimmunity·Michele E YoudRonald B Corley
Sep 13, 2016·Cellular & Molecular Immunology·Laura Gómez-JaramilloAntonio Campos-Caro
Apr 20, 2017·Journal of Hematology & Oncology·Dalia QuwaiderNorma C Gutiérrez
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefan DoerreRonald B Corley
Nov 6, 2009·Journal of Leukocyte Biology·Semra J KirkTheresa H Ward
Sep 1, 1990·European Journal of Immunology·T D RandallR B Corley
Jul 1, 2020·Frontiers in Plant Science·Elsa ArcalísEva Stoger
Jul 1, 1993·Molecular and Cellular Biology·T D RandallR B Corley

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.