PMID: 3768209Jan 1, 1986Paper

Characterization of a rapidly responding animal model for fluoride-stimulated bone formation

Bone
M W LundyD J Baylink

Abstract

Sodium fluoride (NaF) is the single most effective agent for increasing bone volume in the osteoporotic skeleton. However, the mechanism of fluoride-stimulated bone formation is not known, and investigation has been hampered by the lack of a suitable animal model. Young chicks show a rapid skeletal response to NaF that resembles the human skeletal response. This occurs at serum fluoride concentrations comparable to those obtained in humans. Fourteen-day-old chicks treated with NaF (4.2 mM NaF in the drinking water) for 2 weeks showed increases in bone-forming surface in the tibial metaphysis (130% of untreated controls, P less than 0.002), with no change in the number of osteoblasts per length of forming surface (104% of control). The NaF dose dependence of the change in bone-forming surface was biphasic, being optimal at 23 microM fluoride. Linear correlations were observed between dietary NaF and serum fluoride (r = 0.996, P less than 0.001), and serum fluoride and bone fluoride concentrations (r = 0.98, P less than 0.001). Correlations were also observed between the amount of alkaline phosphatase activity in the tibia and the serum fluoride concentration (r = 0.88, P less than 0.03), the serum fluoride concentration and the ...Continue Reading

Citations

Mar 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C G BellowsJ E Aubin
Jan 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P J MarieA Lomri
Nov 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C G BellowsJ N Heersche
May 1, 1992·Calcified Tissue International·M W LundyD J Baylink
Oct 1, 1993·Biomaterials·P SasanaluckitD F Williams
May 10, 2011·Odontology·Hubertine M E WillemsJenneke Klein-Nulend
Nov 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·P A AndersonJ M Clark
Aug 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R T TurnerN H Bell
Apr 1, 1996·Critical Reviews in Clinical Laboratory Sciences·M Kleerekoper
Jun 18, 2003·Critical Reviews in Toxicology·Edward J Calabrese, Linda A Baldwin
Jan 1, 1987·Nutrition and Health·J R Kemm
Nov 1, 1990·Bone and Mineral·P T Cheng, S M Bader

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