Characterization of a riboflavin non-aqueous nanosuspension prepared by bead milling for cutaneous application

Chemical & Pharmaceutical Bulletin
Takayuki SatoKeiji Yamamoto

Abstract

The purpose of this study was to characterize the non-aqueous nanosuspension of a hydrophilic drug prepared by bead milling for cutaneous application. Riboflavin was used as the model hydrophilic drug. The non-aqueous nanosuspensions were prepared by grinding riboflavin with zirconia beads using eight non-aqueous bases. The mean particle size of riboflavin in the suspensions ranged from 206 to 469 nm, as determined by the dynamic light scattering method. Among the well-dispersed samples, riboflavin nanosuspension prepared in oleic acid was selected for evaluation of the drug permeability through rat skin. The cumulative amount and permeation rate of riboflavin from the nanosuspension were approximately three times higher than those for unprocessed riboflavin in oleic acid. Fluorescence imaging of the riboflavin nanosuspension suggested improved penetration of riboflavin into the stratum corneum. Furthermore, the addition of polysorbate 65 or polyglyceryl-6 polyricinoleate to the nanosuspension prepared in oleic acid markedly improved the riboflavin dispersibility. These results show that the preparation of a nanosuspension in a non-aqueous base by bead milling is one of the simple methods to improve the skin permeability of hyd...Continue Reading

References

Mar 1, 1975·The Journal of Investigative Dermatology·T J Franz
Aug 1, 1992·The Journal of Pharmacy and Pharmacology·Y MorimotoH Omiya
Apr 15, 2004·International Journal of Pharmaceutics·A K Kohli, H O Alpar
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jongwon ShimIh-Seop Chang
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michel CormierPete Daddona
Nov 19, 2005·International Journal of Pharmaceutics·Amy C RowatJenifer L Thewalt
Dec 16, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Juergen LademannWolfram Sterry
Aug 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yoshiro TaharaMasahiro Goto
Oct 6, 2009·Chemical & Pharmaceutical Bulletin·Takayuki TakatsukaNaofumi Hashimoto
Dec 5, 2009·The Journal of Pharmacy and Pharmacology·Amra HasanovicClaudia Valenta
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Hiroaki TodoKenji Sugibayashi
Oct 30, 2010·Molecular Membrane Biology·Pinaki DesaiMandip Singh
Jan 29, 2011·International Journal of Pharmaceutics·A Filipowicz, S Wołowiec
Feb 8, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Clara Luisa Domínguez-DelgadoAdriana Ganem
Mar 25, 2011·Expert Opinion on Drug Delivery·Taís GratieriYogeshvar N Kalia
May 21, 2011·International Journal of Pharmaceutics·Khalil MitriRainer H Müller
Oct 27, 2012·International Journal of Pharmaceutics·Keng-Chih LiuIlva D Rupenthal
Mar 28, 2013·Expert Opinion on Drug Delivery·Alexa Patzelt, Juergen Lademann
Feb 4, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·A S RaberC-M Lehr

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Citations

Jan 21, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ali Ahmadi TehraniVahid Ramezani

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