PMID: 708264Jan 1, 1978Paper

Characterization of a Sinbis virus variant with altered host range

Archives of Virology
J Symington, M J Schlesinger


A variant of Sindbis virus which is much more infectious for mouse cells than the standard virus has been examined for biochemical properties which might be responsible for this biological difference. The variant has a much enhanced ability to adsorb to mouse plasmacytoma (MOPC 315) cells, but when these cells were pretreated with heparin, they were able to adsorb the standard virus almost as well as the variant. This suggested that there was a surface charge difference between variant and standard virus. Differential elution of the viruses from hydroxyapatite and the results of isoelectric focusing of the virion glycoproteins substantiate this interpretation. Both viral glycoproteins E1 and E2 from the variant were more negatively charged than those of the standard virus but we were unable to find changes in tryptic peptides of the variant. Differences were found in stability of the two virus strains to heat and proteolytic enzymes.


Jan 1, 1975·Archives of Virology·G WittmannK Bauer
Mar 1, 1977·Infection and Immunity·J SymingtonM J Schlesinger
Jan 1, 1976·Archives of Virology·R Walder, F Liprandi
Apr 1, 1975·Journal of Virology·J Symington, M J Schlesinger
Jan 1, 1973·Archiv für die gesamte Virusforschung·C E PedersenB P Sagik
Jun 1, 1967·Canadian Journal of Microbiology·J B Campbell, J S Colter
Apr 1, 1974·Journal of Virology·C Basilico, G DiMayorca
Sep 1, 1974·Journal of Virology·B M Sefton, K Keegstra
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Sep 1, 1958·The American Journal of Tropical Medicine and Hygiene·D H CLARKE, J CASALS
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·S BENGTSSON

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