PMID: 708264Jan 1, 1978Paper

Characterization of a Sinbis virus variant with altered host range

Archives of Virology
J Symington, M J Schlesinger

Abstract

A variant of Sindbis virus which is much more infectious for mouse cells than the standard virus has been examined for biochemical properties which might be responsible for this biological difference. The variant has a much enhanced ability to adsorb to mouse plasmacytoma (MOPC 315) cells, but when these cells were pretreated with heparin, they were able to adsorb the standard virus almost as well as the variant. This suggested that there was a surface charge difference between variant and standard virus. Differential elution of the viruses from hydroxyapatite and the results of isoelectric focusing of the virion glycoproteins substantiate this interpretation. Both viral glycoproteins E1 and E2 from the variant were more negatively charged than those of the standard virus but we were unable to find changes in tryptic peptides of the variant. Differences were found in stability of the two virus strains to heat and proteolytic enzymes.

References

Jan 1, 1975·Archives of Virology·G WittmannK Bauer
Mar 1, 1977·Infection and Immunity·J SymingtonM J Schlesinger
Jan 1, 1976·Archives of Virology·R Walder, F Liprandi
Apr 1, 1975·Journal of Virology·J Symington, M J Schlesinger
Jan 1, 1973·Archiv für die gesamte Virusforschung·C E PedersenB P Sagik
Jun 1, 1967·Canadian Journal of Microbiology·J B Campbell, J S Colter
Apr 1, 1974·Journal of Virology·C Basilico, G DiMayorca
Sep 1, 1974·Journal of Virology·B M Sefton, K Keegstra
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Jan 1, 1970·Archiv für die gesamte Virusforschung·H R BoseB P Sagik
Sep 1, 1958·The American Journal of Tropical Medicine and Hygiene·D H CLARKE, J CASALS
Aug 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·S BENGTSSON

Related Concepts

Adsorption
Neoglycoproteins
Hemagglutination, Viral
Liquaemin
Isoelectric Focusing
Kyzylagach virus
Surface Properties
Variation (Genetics)
Viral Proteins

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.