PMID: 9661023Jul 14, 1998Paper

Characterization of a staphylococcal plasmid related to pUB110 and carrying two novel genes, vatC and vgbB, encoding resistance to streptogramins A and B and similar antibiotics

Antimicrobial Agents and Chemotherapy
J AllignetN El Solh

Abstract

We isolated and sequenced a plasmid, named pIP1714 (4,978 bp), which specifies resistance to streptogramins A and B and the mixture of these compounds. pIP1714 was isolated from a Staphylococcus cohnii subsp. cohnii strain found in the environment of a hospital where pristinamycin was extensively used. Resistance to both compounds and related antibiotics is encoded by two novel, probably cotranscribed genes, (i) vatC, encoding a 212-amino-acid (aa) acetyltransferase that inactivates streptogramin A and that exhibits 58.2 to 69.8% aa identity with the Vat, VatB, and SatA proteins, and (ii) vgbB, encoding a 295-aa lactonase that inactivates streptogramin B and that shows 67% aa identity with the Vgb lactonase. pIP1714 includes a 2,985-bp fragment also found in two rolling-circle replication and mobilizable plasmids, pUB110 and pBC16, from gram-positive bacteria. In all three plasmids, the common fragment was delimited by two direct repeats of four nucleotides (GGGC) and included (i) putative genes closely related to repB, which encodes a replication protein, and to pre(mob), which encodes a protein required for conjugative mobilization and site-specific recombination, and (ii) sequences very similar to the double- and single-stra...Continue Reading

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Citations

Jun 19, 2002·Antimicrobial Agents and Chemotherapy·Brigitte MalbrunyRoland Leclercq
Nov 13, 2004·The Journal of Antimicrobial Chemotherapy·Brigitte MalbrunyRoland Leclercq
Jan 11, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jari Jalava, Harri Marttila
Oct 25, 2006·Antimicrobial Agents and Chemotherapy·Caroline A ObertElaine I Tuomanen
Dec 24, 2011·Annals of the New York Academy of Sciences·Stefan SchwarzKristina Kadlec
Jan 27, 2019·American Journal of Reproductive Immunology : AJRI·Zhifeng JiaBo Liu
Jun 27, 2000·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·G WernerW Witte
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ellie HershbergerMarcus J Zervos
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Nov 3, 2016·Cold Spring Harbor Perspectives in Medicine·Stefan SchwarzBirte Vester
Mar 18, 2000·Antimicrobial Agents and Chemotherapy·A Seoane, J M García Lobo
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·J HarocheN El Solh
May 26, 2006·Antimicrobial Agents and Chemotherapy·Marco CassoneGianni Pozzi
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Jul 13, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P BémerH Drugeon

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