PMID: 8992025Feb 1, 1996Paper

Characterization of a sterile soft-tissue inflammation model in thoroughbred horses

Journal of Veterinary Pharmacology and Therapeutics
A J GuthrieJ P Nurton

Abstract

This paper describes the use of subcutaneously-placed tissue chambers as a sterile soft-tissue inflammation model in Thoroughbred horses. Acute, non-immune inflammation was initiated by injecting a sterile lambda carrageenan solution into a tissue chamber. This model was used to study the temporal changes in oxygen and carbon dioxide tensions, pH, bicarbonate, protein, albumin, prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) concentrations, cell counts and differential counts in tissue fluid from inflamed tissue chambers and control chambers. Skin temperatures over control and inflamed chambers were also compared. Carrageenan-induced inflammation resulted in significant increases in tissue-fluid carbon dioxide tension, leucocyte count, albumin, and PGE2 and LTB4 concentrations. It also resulted in a significant decrease in tissue fluid pH and HCO3-concentration. Inflammation did not result in significant changes in tissue-fluid protein concentration, differential cell counts or skin temperature over the chambers. The use of this type of tissue chamber is well-suited for studying the pathophysiology of a self-contained, non-immune inflammatory process. The model described in this paper could prove to be very useful in studies ...Continue Reading

References

Dec 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·C R Clarke
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Citations

Jan 1, 2003·Research in Veterinary Science·P SidhuP Lees
Jun 18, 1999·Journal of Veterinary Pharmacology and Therapeutics·P LeesP V Rens
Jun 18, 1999·Journal of Veterinary Pharmacology and Therapeutics·N A AlkatheeriM Lambert
Jun 18, 1999·Journal of Veterinary Pharmacology and Therapeutics·R P HunterA A Dees
Mar 3, 2012·Basic & Clinical Pharmacology & Toxicology·Luiz C Klein-JúniorNara L M Quintão
Oct 21, 2016·Clinical Oral Investigations·Erwin JonkeOleh Andrukhov

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