PMID: 2496662May 15, 1989Paper

Characterization of a superoxide dismutase mimic prepared from desferrioxamine and MnO2

Archives of Biochemistry and Biophysics
W F Beyer, I Fridovich

Abstract

The physicochemical properties of a soluble green complex obtained from the reaction of MnO2 and desferrioxamine have been investigated. The superoxide dismutase mimetic activity of this complex has been previously reported [D. Darr et al. (1987) Arch. Biochem. Biophys. 258, 351-355]. Optical spectra, titration experiments, and metal analyses are consistent with the presence of one gram-atom Mn3+ per mole of desferrioxamine. At least one of the hydroxamate groups is oxidized in the green complex. Reaction of Desferal with MnO2 in the presence of ascorbate yields a more active, pink complex. This pink complex is more stable toward EDTA, suggesting that in it all three hydroxamate groups are intact and ligated to the manganese. The physicochemical properties of these complexes were examined and structures are suggested.

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Citations

Aug 11, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·W L RiesR M Rodriguiz
May 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A G DardenL L Key
Jan 1, 1991·Free Radical Biology & Medicine·E Løvaas, G Carlin
May 1, 1995·Free Radical Biology & Medicine·R S Matthews
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Apr 26, 2003·Bioorganic & Medicinal Chemistry·Opa VajraguptaNaparat Kammasud
Aug 7, 2013·Environmental Science & Technology·Kathrin WuttigPeter L Croot
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B S BerlettE R Stadtman
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Mar 1, 1997·Photochemistry and Photobiology·M Linetsky, B J Ortwerth
Jan 1, 1991·Free Radical Research Communications·A SamuniA Russo
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Aug 1, 1991·Archives of Biochemistry and Biophysics·K C BhuyanI Fridovich
Dec 6, 2003·Reproductive Biomedicine Online·Scott LamondSubhasis Banerjee

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