Characterization of a T-cell-derived mast cell costimulatory activity (MCA) that acts synergistically with interleukin 3 and interleukin 4 on the growth of murine mast cells

Cytokine
E SchmittE Rüde

Abstract

The proliferation of mucosal mast cells (MMC) depends on the presence of interleukin 3 (IL 3) and can be further enhanced by interleukin 4 (IL 4). The supernatant of a TH2 cell clone (ST2/K.9) stimulated by concanavalin A was found to contain a factor, provisionally termed mast cell costimulatory activity (MCA), that substantially enhances the proliferation of MMC promoted by a combination of IL 3 and IL 4. In comparison to other lymphokines MCA is rather resistant to tryptic digestion but is very sensitive to pH values lower than 6.0 and to organic solvents. Chromatographic fractionation of MCA revealed that activity is associated with protein(s) or glycoprotein(s) of 35 to 40 kDa. Partially purified MCA that was functionally free of other T-cell-derived lymphokines did not stimulate mast cell proliferation in the absence of a combination of IL 3 and IL 4. In addition, MCA did not affect the proliferation of mast cells when employed together with either IL 3 or IL 4 alone. Control experiments demonstrated that MCA is identical to neither the T-cell-derived lymphokines IL 2 to IL 6, IL 9, interferon gamma, tumor necrosis factor alpha or beta, or granulocyte-macrophage colony-stimulating factor (CSF), nor to IL 7, granulocyte CS...Continue Reading

References

Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C UyttenhoveJ Van Snick
Jan 1, 1987·Annual Review of Immunology·W E Paul, J Ohara
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P W Gray, D V Goeddel
Apr 1, 1984·Immunology Today·E E Jarrett, D M Haig

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Citations

Feb 3, 2011·Cancer Metastasis Reviews·Khashayarsha KhazaieDavid J Bentrem
Jan 12, 1994·Journal of Immunological Methods·J F SchlaakB Fleischer
Dec 20, 2002·Nature·Christophe Benoist, Diane Mathis
May 23, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StassenE Schmitt
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter StopferThomas Hehlgans

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