PMID: 9443043Jan 27, 1998Paper

Characterization of a t(8;13)(p11;q11-12) in an atypical myeloproliferative disorder

Genes, Chromosomes & Cancer
D SmedleyJ Shipley

Abstract

Fourteen cases of an atypical myeloproliferative disorder associated with consistent translocations involving 8p11-12 have previously been described. A t(8;13)(p11;q11-12) was the most common, but variant t(8;9)(p11-12;q32-34) and t(6;8)(q27;p12) were also reported. Here we have used a series of yeast artificial chromosomes (YACs) derived from the 8p11 and 13q11-12 regions to analyse one of the t(8;13) cases by fluorescence in situ hybridization (FISH). YACs flanking the 13q11-12 breakpoint and spanning the 8p11 breakpoint have been isolated. These YACs will facilitate characterization of the genes involved in this rearrangement.

Citations

Jun 20, 2006·Best Practice & Research. Clinical Haematology·Ayalew Tefferi, Gary Gilliland
Oct 20, 2001·Best Practice & Research. Clinical Haematology·A J BenchA R Green
Sep 16, 1999·Genomics·D SmedleyJ Shipley

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