PMID: 7535918Nov 1, 1994Paper

Characterization of a transient outward current in a rapidly adapting insect mechanosensory neuron

Pflügers Archiv : European journal of physiology
Päivi H Torkkeli, Andrew S French

Abstract

This paper describes the first voltage-clamp recordings from an arthropod cuticular sensory neuron. In the femoral tactile spine neuron of the cockroach Periplaneta americana, a rapidly activating and inactivating outward current, IA, appeared when the neuron was hyperpolarized for a short period before a depolarizing test pulse. IA could be separated from the other outward currents using 5 mM 4-aminopyridine (4-AP), which specifically blocked it. Tetraethylammonium (TEA), (50 mM) did not remove IA, but decreased the steady-state outward current by about 50%. The threshold for IA activation was about -75 mV. The minimum activation and inactivation time constants were approximately 0.2 ms and 15 ms, respectively. The voltage dependencies of activation and inactivation were well fit-ted by Boltzmann distributions, giving values of membrane potential at half-maximal activation (V50) equal to -56.5 mV and an equivalent gating charge of n = 3.9 for activation and V50 = -86.7 mV and n = 3.4 for inactivation. In current-clamp recordings, 4-AP reversibly reduced the cell's normal adaptation by lowering the threshold for action potentials, but did not affect the amplitude or duration of single action potentials. These results indicate t...Continue Reading

References

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Citations

Aug 17, 2005·The European Journal of Neuroscience·Izabela Panek, Päivi H Torkkeli
Aug 3, 2002·The European Journal of Neuroscience·Izabela PanekPäivi H Torkkeli
Jul 13, 2004·The European Journal of Neuroscience·Ewald GinglPäivi H Torkkeli
Jun 13, 2003·Journal of Neurophysiology·Izabela PanekPäivi H Torkkeli
Dec 21, 2002·The European Journal of Neuroscience·Ulli Höger, Andrew S French
Oct 27, 1997·Journal of Neurophysiology·U HögerA S French
Jun 16, 1999·Journal of Neurophysiology·S I SekizawaP H Torkkeli

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